An electroencephalogram microdisplay to visualize neuronal activity on the brain surface

Author:

Tchoe Youngbin12ORCID,Wu Tianhai1,U Hoi Sang1,Roth David M.13,Kim Dongwoo1ORCID,Lee Jihwan1ORCID,Cleary Daniel R.145ORCID,Pizarro Patricia16ORCID,Tonsfeldt Karen J.17ORCID,Lee Keundong1ORCID,Chen Po Chun1ORCID,Bourhis Andrew M.1ORCID,Galton Ian8ORCID,Coughlin Brian910ORCID,Yang Jimmy C.1112ORCID,Paulk Angelique C.910ORCID,Halgren Eric5ORCID,Cash Sydney S.910ORCID,Dayeh Shadi A.113ORCID

Affiliation:

1. Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.

2. Department of Biomedical Engineering, Ulsan National Institute of Science and Technology, Ulsan 44919, Korea.

3. Department of Anesthesiology, University of California, San Diego, La Jolla, CA 92093, USA.

4. Center for the Future of Surgery, Department of Surgery, University of California, San Diego, La Jolla, CA 92093, USA.

5. Department of Neurological Surgery, University of California, San Diego, La Jolla, CA 92093, USA.

6. Department of Neurological Surgery, Oregon Health & Science University, Mail code CH8N, 3303 SW Bond Avenue, Portland, OR 97239, USA.

7. Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California, San Diego, La Jolla, CA 92093, USA.

8. Department of Electrical and Computer Engineering, University of California, San Diego, La Jolla, CA 92093, USA.

9. Department of Neurology, Center for Neurotechnology and Neurorecovery, Massachusetts General Hospital, Boston, MA 02114, USA.

10. Department of Neurology, Harvard Medical School, Boston, MA 02115, USA.

11. Department of Neurosurgery, Massachusetts General Hospital, Boston, MA 02114, USA.

12. Department of Neurological Surgery, Ohio State University, Columbus, OH 43210, USA.

13. Departments of Radiology and Neurosciences, University of California, San Diego, La Jolla, CA 92093, USA.

Abstract

Functional mapping during brain surgery is applied to define brain areas that control critical functions and cannot be removed. Currently, these procedures rely on verbal interactions between the neurosurgeon and electrophysiologist, which can be time-consuming. In addition, the electrode grids that are used to measure brain activity and to identify the boundaries of pathological versus functional brain regions have low resolution and limited conformity to the brain surface. Here, we present the development of an intracranial electroencephalogram (iEEG)–microdisplay that consists of freestanding arrays of 2048 GaN light-emitting diodes laminated on the back of micro-electrocorticography electrode grids. With a series of proof-of-concept experiments in rats and pigs, we demonstrate that these iEEG-microdisplays allowed us to perform real-time iEEG recordings and display cortical activities by spatially corresponding light patterns on the surface of the brain in the surgical field. Furthermore, iEEG-microdisplays allowed us to identify and display cortical landmarks and pathological activities from rat and pig models. Using a dual-color iEEG-microdisplay, we demonstrated coregistration of the functional cortical boundaries with one color and displayed the evolution of electrical potentials associated with epileptiform activity with another color. The iEEG-microdisplay holds promise to facilitate monitoring of pathological brain activity in clinical settings.

Publisher

American Association for the Advancement of Science (AAAS)

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3