Triple-modality therapy maximizes antitumor immune responses in a mouse model of mesothelioma-Reference-Cited by-同舟云学术

Triple-modality therapy maximizes antitumor immune responses in a mouse model of mesothelioma

Published:2021-04-14 Issue:589 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Murakami Junichi¹²,Wu Licun¹^ORCID,Kohno Mikihiro¹³,Chan Mei-Lin¹^ORCID,Zhao Yidan¹^ORCID,Yun Zhihong¹^ORCID,Cho B. C. John⁴^ORCID,de Perrot Marc¹³⁵^ORCID

Affiliation:

1. Latner Thoracic Surgery Research Laboratories, Toronto General Hospital Research Institute, University Health Network, Toronto, Ontario M5G 1L7, Canada.

2. Department of Surgery and Clinical Science, Division of Chest Surgery, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi 755-8505, Japan.

3. Division of Thoracic Surgery, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2C4, Canada.

4. Department of Radiation Oncology, Princess Margaret Cancer Centre, University Health Network, Toronto, Ontario M5G 2C1, Canada.

5. Department of Immunology, University of Toronto, Toronto, Ontario M5S 1A8, Canada.

Abstract

Combining IL-15 superagonist and anti-GITR agonist therapy enhances antitumor effects of radiation therapy in a mouse model of mesothelioma.

Funder

Uehara Memorial Foundation

Princess Margaret Cancer Foundation

Toronto General and Western Hospital Foundation

Canadian Mesothelioma Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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