Heightened resistance to host type 1 interferons characterizes HIV-1 at transmission and after antiretroviral therapy interruption

Author:

Gondim Marcos V. P.1ORCID,Sherrill-Mix Scott12ORCID,Bibollet-Ruche Frederic12,Russell Ronnie M.12ORCID,Trimboli Stephanie3,Smith Andrew G.4,Li Yingying1,Liu Weimin1,Avitto Alexa N.5ORCID,DeVoto Julia C.6,Connell Jesse12ORCID,Fenton-May Angharad E.7ORCID,Pellegrino Pierre8,Williams Ian8ORCID,Papasavvas Emmanouil9,Lorenzi Julio C. C.10ORCID,Salantes D. Brenda11ORCID,Mampe Felicity1,Monroy M. Alexandra1,Cohen Yehuda Z.12ORCID,Heath Sonya13ORCID,Saag Michael S.13ORCID,Montaner Luis J.9ORCID,Collman Ronald G.12ORCID,Siliciano Janet M.14ORCID,Siliciano Robert F.1415ORCID,Plenderleith Lindsey J.1617,Sharp Paul M.1617,Caskey Marina10ORCID,Nussenzweig Michel C.1018ORCID,Shaw George M.12ORCID,Borrow Persephone7ORCID,Bar Katharine J.12ORCID,Hahn Beatrice H.12ORCID

Affiliation:

1. Department of Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Department of Microbiology, University of Pennsylvania, Philadelphia, PA 19104, USA.

3. University of Massachusetts Medical School, Worcester, MA 01655, USA.

4. WuXi AppTec Inc., Philadelphia, PA 19112, USA.

5. Gene Therapy Program, University of Pennsylvania, Philadelphia, PA 19104, USA.

6. Department of Pathology and Laboratory Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.

7. Nuffield Department of Clinical Medicine, University of Oxford, Oxford OX3 7FZ, UK.

8. Centre for Clinical Research in Infection and Sexual Health, Institute for Global Health, University College London, London WC1E 6JB, UK.

9. Vaccine and Immunotherapy Center, Wistar Institute, Philadelphia, PA 19104, USA.

10. Laboratory of Molecular Immunology, Rockefeller University, New York, NY 10065, USA.

11. Century Therapeutics, Philadelphia, PA 19104, USA.

12. Sanofi, Bridgewater, NJ 08807, USA.

13. Department of Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

14. Department of Medicine, Johns Hopkins University, Baltimore, MD 21205, USA.

15. Howard Hughes Medical Institute, Johns Hopkins University, Baltimore, MD 21205, USA.

16. Institute of Evolutionary Biology, University of Edinburgh, Edinburgh EH9 3FL, UK.

17. Centre for Immunity, Infection and Evolution, University of Edinburgh, Edinburgh EH9 3FL, UK.

18. Howard Hughes Medical Institute, Rockefeller University, New York, NY 10065, USA.

Abstract

Interferon-mediated pressures vary throughout HIV-1 infection but are the highest during viral rebound after treatment interruption.

Funder

National Institutes of Health

Medical Research Council

Bill and Melinda Gates Foundation

NIH Office of the Director

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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