Circulating proteins protect against renal decline and progression to end-stage renal disease in patients with diabetes

Author:

Md Dom Zaipul I.12ORCID,Satake Eiichiro12ORCID,Skupien Jan3,Krolewski Bozena12,O’Neil Kristina1ORCID,Willency Jill A.4ORCID,Dillon Simon T.25ORCID,Wilson Jonathan M.4ORCID,Kobayashi Hiroki12ORCID,Ihara Katsuhito12,Libermann Towia A.25,Pragnell Marlon6ORCID,Duffin Kevin L.4ORCID,Krolewski Andrzej S.12ORCID

Affiliation:

1. Research Division, Joslin Diabetes Center, Boston, MA 02215, USA.

2. Department of Medicine, Harvard Medical School, Boston, MA 02215, USA.

3. Department of Metabolic Diseases, Jagiellonian University Medical College, 31-008 Krakow, Poland.

4. Diabetes and Complication Department, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46225, USA.

5. Genomics, Proteomics, Bioinformatics and Systems Biology Center, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA.

6. JDRF International, New York, NY 10281, USA.

Abstract

Global proteomics profiling identified FGF20, TNFSF12, and ANGPT1 as protective against progression of renal function decline in those with diabetes.

Funder

National Institutes of Health

JDRF

Novo Nordisk Foundation Center for Basic Metabolic Research

The Sunstar Foundation (Hiroo Kaneda Scholarship) Japan

The Foundation for Growth Science Japan

The Uehara Memorial Foundation (Postdoctoral Fellowship) Japan

NIH Diabetes Research Center

the Japan Society for the Promotion of Science

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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