ALT neuroblastoma chemoresistance due to telomere dysfunction–induced ATM activation is reversible with ATM inhibitor AZD0156-Reference-Cited by-同舟云学术

ALT neuroblastoma chemoresistance due to telomere dysfunction–induced ATM activation is reversible with ATM inhibitor AZD0156

Published:2021-08-18 Issue:607 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Koneru Balakrishna¹²³^ORCID,Farooqi Ahsan¹^ORCID,Nguyen Thinh H.¹^ORCID,Chen Wan Hsi¹^ORCID,Hindle Ashly¹³,Eslinger Cody¹^ORCID,Makena Monish Ram¹^ORCID,Burrow Trevor A.¹,Wilson Joanne⁴^ORCID,Smith Aaron⁴^ORCID,Pilla Reddy Venkatesh⁵^ORCID,Cadogan Elaine⁴^ORCID,Durant Stephen T.⁴^ORCID,Reynolds C. Patrick¹²³⁶^ORCID

Affiliation:

1. Cancer Center, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

2. Department of Pediatrics, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

3. Department of Cell Biology and Biochemistry, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

4. Early Oncology, R&D AstraZeneca, Cambridge CB10 1XL, UK.

5. Clinical Pharmacology and Quantitative Pharmacology, Biopharmaceuticals R&D, AstraZeneca, Cambridge SG8 6EE, UK.

6. Department of Internal Medicine, School of Medicine, Texas Tech University Health Sciences Center, Lubbock, TX 79430, USA.

Abstract

ATM activation at telomeres confers chemoresistance in ALT neuroblastoma and is reversible in preclinical models by ATM knockdown or inhibition.

Funder

National Cancer Institute

Alex’s Lemonade Stand Foundation for Childhood Cancer

Cancer Prevention and Research Institute of Texas

FUNDING

CANDU Owners Group

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference60 articles.

1. Hallmarks of Cancer: The Next Generation

2. Specific Association of Human Telomerase Activity with Immortal Cells and Cancer

3. Prevalence of the Alternative Lengthening of Telomeres Telomere Maintenance Mechanism in Human Cancer Subtypes

4. Assaying and investigating Alternative Lengthening of Telomeres activity in human cells and cancers

5. Telomere maintenance by recombination in human cells

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