A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence-Reference-Cited by-同舟云学术

A genome-wide CRISPR-based screen identifies KAT7 as a driver of cellular senescence

Published:2021-01-06 Issue:575 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Wang Wei¹²³⁴^ORCID,Zheng Yuxuan⁵⁶^ORCID,Sun Shuhui¹³⁴^ORCID,Li Wei⁷^ORCID,Song Moshi¹⁴⁸,Ji Qianzhao¹⁴,Wu Zeming²⁴,Liu Zunpeng²⁴,Fan Yanling⁹¹⁰,Liu Feifei¹,Li Jingyi¹⁴^ORCID,Esteban Concepcion Rodriguez¹¹,Wang Si¹⁷⁸^ORCID,Zhou Qi²⁴⁸^ORCID,Belmonte Juan Carlos Izpisua¹¹^ORCID,Zhang Weiqi⁴⁷⁸⁹¹⁰^ORCID,Qu Jing²⁴⁸^ORCID,Tang Fuchou⁵⁶^ORCID,Liu Guang-Hui¹³⁴⁷⁸^ORCID

Affiliation:

1. State Key Laboratory of Membrane Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China.

2. State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing 100101, China.

3. National Laboratory of Biomacromolecules, CAS Center for Excellence in Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China.

4. University of Chinese Academy of Sciences, Beijing 100049, China.

5. Beijing Advanced Innovation Center for Genomics, Biomedical Pioneering Innovation Center, School of Life Sciences, Peking University, Beijing 100871, China.

6. Peking-Tsinghua Center for Life Sciences, Academy for Advanced Interdisciplinary Studies, Peking University, Beijing 100871, China.

7. Advanced Innovation Center for Human Brain Protection, National Clinical Research Center for Geriatric Disorders, Xuanwu Hospital Capital Medical University, Beijing 100053, China.

8. Institute for Stem Cell and Regeneration, Chinese Academy of Sciences, Beijing 100101, China.

9. CAS Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics, Chinese Academy of Sciences, Beijing 100101, China.

10. China National Center for Bioinformation, Chinese Academy of Sciences, Beijing 100101, China.

11. Gene Expression Laboratory, Salk Institute for Biological Studies, La Jolla, CA 92037, USA.

Abstract

Inactivation of the histone acetyltransferase gene KAT7 prolongs survival in naturally aged mice and progeroid mice that age prematurely.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference63 articles.

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4. The Role of Senescence in the Development of Nonalcoholic Fatty Liver Disease and Progression to Nonalcoholic Steatohepatitis

5. The Hallmarks of Aging

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