ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy-Reference-Cited by-同舟云学术

ULK1 inhibition promotes oxidative stress–induced differentiation and sensitizes leukemic stem cells to targeted therapy

Published:2021-09-29 Issue:613 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ianniciello Angela¹^ORCID,Zarou Martha M.¹^ORCID,Rattigan Kevin M.¹^ORCID,Scott Mary¹^ORCID,Dawson Amy¹^ORCID,Dunn Karen²^ORCID,Brabcova Zuzana¹,Kalkman Eric R.¹^ORCID,Nixon Colin³^ORCID,Michie Alison M.²^ORCID,Copland Mhairi²^ORCID,Vetrie David¹^ORCID,Ambler Martin⁴^ORCID,Saxty Barbara⁴,Helgason G. Vignir¹^ORCID

Affiliation:

1. Wolfson Wohl Cancer Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G61 1QH, UK.

2. Paul O’Gorman Leukaemia Research Centre, Institute of Cancer Sciences, University of Glasgow, Glasgow G12 0ZD, UK.

3. Cancer Research UK Beatson Institute, Glasgow G61 1BD, UK.

4. LifeArc, Accelerator Building, Open Innovation Campus, Stevenage SG1 2FX, UK.

Abstract

ULK1 inhibition increases the sensitivity of leukemia stem cells to TKI therapy by modulating energy and redox balance.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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