scRNA-seq of human vitiligo reveals complex networks of subclinical immune activation and a role for CCR5 in T reg function

Author:

Gellatly Kyle J.1ORCID,Strassner James P.2ORCID,Essien Kingsley2ORCID,Refat Maggi Ahmed2,Murphy Rachel L.1,Coffin-Schmitt Anthony1,Pandya Amit G.3ORCID,Tovar-Garza Andrea3ORCID,Frisoli Michael L.2ORCID,Fan Xueli2,Ding Xiaolan4,Kim Evangeline E.2,Abbas Zainab2ORCID,McDonel Patrick1ORCID,Garber Manuel1ORCID,Harris John E.2ORCID

Affiliation:

1. Program in Bioinformatics and Integrative Biology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

2. Department of Dermatology, University of Massachusetts Medical School, Worcester, MA 01655, USA.

3. Department of Dermatology, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

4. Department of Dermatology, Peking University People’s Hospital, Beijing, China.

Abstract

scRNA-seq of human vitiligo samples reveals complex autoimmune networks, including a role for CCR5 in T reg function.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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