Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis-Reference-Cited by-同舟云学术

Targeting epigenetically maladapted vascular niche alleviates liver fibrosis in nonalcoholic steatohepatitis

Published:2021-10-06 Issue:614 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Zhang Hua¹^ORCID,Ma Yongyuan¹^ORCID,Cheng Xinying¹^ORCID,Wu Dongbo²^ORCID,Huang Xingming¹^ORCID,Chen Bin³,Ren Yafeng¹^ORCID,Jiang Wei²^ORCID,Tang Xiaoqiang¹^ORCID,Bai Ting⁴,Chen Yutian¹^ORCID,Zhao Yilin¹^ORCID,Zhang Chunxue¹,Xiao Xia¹^ORCID,Liu Jing¹,Deng Yue⁵,Ye Tinghong¹^ORCID,Chen Lu¹^ORCID,Liu Han-Min¹,Friedman Scott L.⁶^ORCID,Chen Liping⁷^ORCID,Ding Bi-Sen¹⁶⁸^ORCID,Cao Zhongwei¹⁶^ORCID

Affiliation:

1. Key Laboratory of Birth Defects and Related Diseases of Women and Children of MOE, State Key Laboratory of Biotherapy, West China Second University Hospital, Sichuan University, Chengdu 610041, China.

2. Center of Infectious Diseases, West China Hospital, Sichuan University, Chengdu 610041, China.

3. Institutes for Systems Genetics, Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.

4. Department of Cardiology, The First Affiliated Hospital, Xi’an Jiaotong University, Xi’an 710061, China.

5. Peking University China-Japan Friendship School of Clinical Medicine, Beijing 100029, China.

6. Fibrosis Research Program, Division of Pulmonary and Critical Care Medicine, Division of Liver Diseases, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

7. Department of Biliary Surgery, West China Hospital, Sichuan University, Chengdu 610041, China.

8. Division of Regenerative Medicine, Weill Cornell Medicine, New York, NY 10065, USA.

Abstract

Epigenetic targeting of the maladaptive vascular niche in fibrotic liver blocks fibrosis by alleviating fibrogenic angiocrine IGFBP7 and ADAMTS1.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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