Macrophage depletion induces edema through release of matrix-degrading proteases and proteoglycan deposition-Reference-Cited by-同舟云学术

Macrophage depletion induces edema through release of matrix-degrading proteases and proteoglycan deposition

Published:2021-06-16 Issue:598 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bissinger Stefan¹^ORCID,Hage Carina¹,Wagner Vinona¹,Maser Ilona-Petra¹,Brand Verena¹,Schmittnaegel Martina¹²,Jegg Anna-Maria¹,Cannarile Michael¹,Watson Carl^ORCID,Klaman Irina¹^ORCID,Rieder Natascha¹,González Loyola Alejandra³^ORCID,Petrova Tatiana V.³^ORCID,Cassier Philippe A.⁴^ORCID,Gomez-Roca Carlos⁵,Sibaud Vincent⁵,De Palma Michele²^ORCID,Hoves Sabine¹^ORCID,Ries Carola H.¹^ORCID

Affiliation:

1. Roche Pharma Research and Early Development, Discovery Oncology, Roche Innovation Center Munich, 82377 Penzberg, Germany.

2. Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, Swiss Federal Institute of Technology in Lausanne (EPFL), 1015 Lausanne, Switzerland.

3. Department of Oncology, University of Lausanne (UNIL) and Ludwig Institute for Cancer Research Lausanne (LICR), 1066 Epalinges, Switzerland.

4. Department of Medical Oncology, Centre Léon Bérard, 69008 Lyon, France.

5. Institut Claudius Regaud/Institut Universitaire du Cancer, Toulouse Oncopole, 31300 Toulouse, France.

Abstract

Macrophage depletion by colony-stimulating factor 1 receptor blockade alters extracellular matrix homeostasis and promotes skin edema.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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