ABCB10 exports mitochondrial biliverdin, driving metabolic maladaptation in obesity

Author:

Shum Michael123ORCID,Shintre Chitra A.4,Althoff Thorsten5ORCID,Gutierrez Vincent123,Segawa Mayuko123ORCID,Saxberg Alexandra D.6ORCID,Martinez Melissa6ORCID,Adamson Roslin4ORCID,Young Margaret R.4ORCID,Faust Belinda4,Gharakhanian Raffi123ORCID,Su Shi7,Chella Krishnan Karthickeyan89ORCID,Mahdaviani Kiana17,Veliova Michaela2ORCID,Wolf Dane M.17ORCID,Ngo Jennifer12310ORCID,Nocito Laura7,Stiles Linsey12,Abramson Jeff5,Lusis Aldons J.81112,Hevener Andrea L.1ORCID,Zoghbi Maria E.6ORCID,Carpenter Elisabeth P.4ORCID,Liesa Marc123ORCID

Affiliation:

1. Department of Medicine, Division of Endocrinology, David Geffen School of Medicine at UCLA, 650 Charles E. Young Dr., Los Angeles, CA 90095, USA.

2. Department of Molecular and Medical Pharmacology, David Geffen School of Medicine at UCLA, 650 Charles E. Young Dr., Los Angeles, CA 90095, USA.

3. Molecular Biology Institute at UCLA, 611 Charles E. Young Drive East, Los Angeles, CA 90095-1570, USA.

4. Center for Medicines Discovery, University of Oxford, Oxfordshire OX3 7DQ, UK.

5. Department of Physiology, University of California, Los Angeles, 650 Charles E. Young Dr., Los Angeles, CA 90095, USA.

6. Department of Molecular Cell Biology, School of Natural Sciences, University of California, Merced, 5200 North Lake Rd., Merced, CA 95343, USA.

7. Evans Biomedical Research Center, Boston University School of Medicine, 650 Albany St., Boston, MA 02118, USA.

8. Department of Human Genetics, David Geffen School of Medicine at UCLA, 650 Charles E. Young Dr., Los Angeles, CA 90095, USA.

9. Department of Pharmacology and Systems Physiology, University of Cincinnati College of Medicine, 231 Albert Sabin Way, Cincinnati, OH 45267-0575, USA.

10. Department of Chemistry and Biochemistry, University of California, Los Angeles, Los Angeles, CA 90095, USA.

11. Department of Medicine, Division of Cardiology, David Geffen School of Medicine at UCLA, 650 Charles E. Young Dr., Los Angeles, CA 90095, USA.

12. Department of Microbiology, Immunology and Molecular Genetics, David Geffen School of Medicine at UCLA, 650 Charles E. Young Dr., Los Angeles, CA 90095, USA.

Abstract

ABCB10 in the liver impairs insulin signaling and promotes hyperglycemia and steatosis.

Funder

National Institutes of Health

Wellcome

Tourettes Action

Takeda Canada

University of California, Los Angeles

Canadian Diabetes Association

Innovative Medicines Initiative

Wellcome Trust Centre for Mitochondrial Research

American Heart Association

Universidade de Santiago de Compostela

BNORC

Department of medicine, UCLA

UCLA Clinical and translational science institute

UCLA and UCSD Diabetes Endocrinology research Center

Boston Nutrition Obesity Research Center

UCLA:DDRC NIH

USC-ALPD NIH Pilot grant

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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