Integrated trajectories of the maternal metabolome, proteome, and immunome predict labor onset

Author:

Stelzer Ina A.1ORCID,Ghaemi Mohammad S.12,Han Xiaoyuan13ORCID,Ando Kazuo1ORCID,Hédou Julien J.1ORCID,Feyaerts Dorien1ORCID,Peterson Laura S.4ORCID,Rumer Kristen K.1ORCID,Tsai Eileen S.1ORCID,Ganio Edward A.1ORCID,Gaudillière Dyani K.5ORCID,Tsai Amy S.1ORCID,Choisy Benjamin1ORCID,Gaigne Lea P.1ORCID,Verdonk Franck1ORCID,Jacobsen Danielle1ORCID,Gavasso Sonia16,Traber Gavin M.7ORCID,Ellenberger Mathew7ORCID,Stanley Natalie18,Becker Martin18ORCID,Culos Anthony18ORCID,Fallahzadeh Ramin18ORCID,Wong Ronald J.4ORCID,Darmstadt Gary L.9ORCID,Druzin Maurice L.10ORCID,Winn Virginia D.11ORCID,Gibbs Ronald S.10ORCID,Ling Xuefeng B.12,Sylvester Karl12,Carvalho Brendan1,Snyder Michael P.7ORCID,Shaw Gary M.4ORCID,Stevenson David K.4,Contrepois Kévin7ORCID,Angst Martin S.1ORCID,Aghaeepour Nima148ORCID,Gaudillière Brice14ORCID

Affiliation:

1. Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

2. Digital Technologies Research Centre, National Research Council Canada, Toronto, ON M5T 3J1, Canada.

3. Department of Biomedical Sciences, University of the Pacific, Arthur A. Dugoni School of Dentistry, San Francisco, CA 94103, USA.

4. Division of Neonatal and Developmental Medicine, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

5. Division of Plastic and Reconstructive Surgery, Department of Surgery, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

6. Department of Neurology, NeuroSys-Med, Haukeland University Hospital, 5021 Bergen, Norway.

7. Department of Genetics, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

8. Department of Biomedical Data Science, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

9. Division of Neonatology, Department of Pediatrics, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

10. Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

11. Department of Obstetrics and Gynecology, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

12. Department of Surgery, Stanford University School of Medicine, Palo Alto, CA 94305, USA.

Abstract

Peripheral blood dynamics in the 100 days before delivery reveal a transition from pregnancy maintenance to prelabor biology.

Funder

National Institutes of Health

Doris Duke Charitable Foundation

March of Dimes Foundation

American Heart Association

Evergreen State College Foundation

Stanford Maternal and Child Health Research Institute

Deutsche Forschungsgemeinschaft

NIH

Gates Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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