Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia-Reference-Cited by-同舟云学术

Repurposed drugs block toxin-driven platelet clearance by the hepatic Ashwell-Morell receptor to clear Staphylococcus aureus bacteremia

Published:2021-03-24 Issue:586 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sun Josh¹²³^ORCID,Uchiyama Satoshi¹^ORCID,Olson Joshua¹,Morodomi Yosuke⁴,Cornax Ingrid¹,Ando Nao¹,Kohno Yohei¹,Kyaw May M. T.¹,Aguilar Bernice¹^ORCID,Haste Nina M.¹²³^ORCID,Kanaji Sachiko⁴,Kanaji Taisuke⁴,Rose Warren E.⁵^ORCID,Sakoulas George²,Marth Jamey D.⁶⁷,Nizet Victor¹²³^ORCID

Affiliation:

1. Biomedical Sciences Graduate Program, UC San Diego, La Jolla, CA 92093, USA.

2. Department of Pediatrics, UC San Diego, La Jolla, CA 92093, USA.

3. Skaggs School of Pharmacy and Pharmaceutical Sciences, UC San Diego, La Jolla, CA 92093, USA.

4. Department of Molecular Medicine, MERU-Roon Research Center on Vascular Biology, Scripps Research, La Jolla, CA 92037, USA.

5. School of Pharmacy, University of Wisconsin, Madison, WI 53705, USA.

6. Center for Nanomedicine, UC Santa Barbara, Santa Barbara, CA 93106, USA.

7. Sanford Burnham Prebys Medical Discovery Institute, UC Santa Barbara, Santa Barbara, CA 93106, USA.

Abstract

The clinically approved drugs ticagrelor and oseltamivir fortify a pathway of platelet-mediated immunity to clear staphylococcal bacteremia in mice.

Funder

National Institutes of Health