Mechanism and reversal of drug-induced nephrotoxicity on a chip-Reference-Cited by-同舟云学术

Mechanism and reversal of drug-induced nephrotoxicity on a chip

Published:2021-02-24 Issue:582 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Cohen Aaron¹²^ORCID,Ioannidis Konstantinos¹^ORCID,Ehrlich Avner¹²^ORCID,Regenbaum Shaun¹³^ORCID,Cohen Merav¹²^ORCID,Ayyash Muneef¹³,Tikva Sigal Shafran⁴,Nahmias Yaakov¹²³^ORCID

Affiliation:

1. Grass Center for Bioengineering, Benin School of Computer Science and Engineering, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

2. Department of Cell and Developmental Biology, Silberman Institute of Life Sciences, The Hebrew University of Jerusalem, Jerusalem 91904, Israel.

3. Tissue Dynamics, Jerusalem 91904, Israel.

4. Hadassah Medical Center, Jerusalem 91904, Israel.

Abstract

Sensor-embedded spheroids-on-a-chip reveal the mechanisms of cisplatin- and cyclosporine-induced nephrotoxicity and identify a potential therapeutic.

Funder

H2020 European Research Council

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference52 articles.

1. Nephrotoxic medication exposure in U.S. Adults with predialysis chronic kidney disease: Health services utilization and cost outcomes;Davis-Ajami M. L.;J. Manag. Care Spec. Pharm.,2016

2. Drug-induced acute kidney injury

3. Crystal-induced acute renal failure

4. Drug-Induced Thrombotic Microangiopathy

5. Drug-associated thrombotic thrombocytopenic purpura-hemolytic uremic syndrome

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