Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel-Reference-Cited by-同舟云学术

Chromosomal instability sensitizes patient breast tumors to multipolar divisions induced by paclitaxel

Published:2021-09-08 Issue:610 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Scribano Christina M.¹^ORCID,Wan Jun²^ORCID,Esbona Karla³^ORCID,Tucker John B.⁴^ORCID,Lasek Amber⁵^ORCID,Zhou Amber S.¹^ORCID,Zasadil Lauren M.¹^ORCID,Molini Ryan⁵,Fitzgerald Jonathan¹,Lager Angela M.⁶^ORCID,Laffin Jennifer J.⁶^ORCID,Correia-Staudt Kayla³,Wisinski Kari B.³,Tevaarwerk Amye J.³^ORCID,O’Regan Ruth³^ORCID,McGregor Stephanie M.⁷^ORCID,Fowler Amy M.⁸⁹¹⁰^ORCID,Chappell Richard J.¹¹,Bugni Tim S.¹²^ORCID,Burkard Mark E.³¹⁰¹³^ORCID,Weaver Beth A.⁵¹⁰¹³^ORCID

Affiliation:

1. Molecular and Cellular Pharmacology Graduate Training Program, University of Wisconsin, Madison, WI 53705, USA.

2. Physiology Graduate Training Program, University of Wisconsin, Madison, WI 53705, USA.

3. Department of Medicine, University of Wisconsin, Madison, WI 53705, USA.

4. Cancer Biology Graduate Training Program, University of Wisconsin, Madison, WI 53705, USA.

5. Department of Cell and Regenerative Biology, University of Wisconsin, Madison, WI 53705, USA.

6. Wisconsin State Laboratory of Hygiene, Madison, WI 53705, USA.

7. Department of Pathology and Laboratory Medicine, University of Wisconsin, Madison, WI 53705, USA.

8. Department of Radiology, University of Wisconsin, Madison, WI 53792, USA.

9. Department of Medical Physics, University of Wisconsin, Madison, WI 53705, USA.

10. Carbone Cancer Center, University of Wisconsin-Madison, Madison, WI 53705, USA.

11. Department of Statistics, University of Wisconsin, Madison, WI 53705, USA.

12. School of Pharmacy, University of Wisconsin, Madison, WI 53705, USA.

13. Department of Oncology/McArdle Laboratory for Cancer Research, University of Wisconsin, Madison, WI 53705, USA.

Abstract

Paclitaxel cytotoxicity in breast tumors depends on multipolar spindle maintenance and preexisting chromosomal instability.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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