Unfolded protein response inhibitors cure group A streptococcal necrotizing fasciitis by modulating host asparagine-Reference-Cited by-同舟云学术

Unfolded protein response inhibitors cure group A streptococcal necrotizing fasciitis by modulating host asparagine

Published:2021-08-04 Issue:605 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Anand Aparna¹^ORCID,Sharma Abhinay¹^ORCID,Ravins Miriam¹,Biswas Debabrata²³,Ambalavanan Poornima²³,Lim Kimberly Xuan Zhen²³,Tan Rachel Ying Min²³^ORCID,Johri Atul Kumar⁴,Tirosh Boaz⁵^ORCID,Hanski Emanuel¹²³^ORCID

Affiliation:

1. Department of Microbiology and Molecular Genetics, The Institute for Medical Research, Israel-Canada (IMRIC), Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

2. Singapore-HUJ Alliance for Research and Enterprise, MMID Phase II, Campus for Research Excellence and Technological Enterprise (CREATE), Singapore 117576, Singapore.

3. Department of Microbiology and Immunology, National University of Singapore, Singapore 138602, Singapore.

4. School of Life Sciences, Jawaharlal Nehru University, New Mehrauli Road, New Delhi 110067, India.

5. Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University of Jerusalem, Jerusalem 9112102, Israel.

Abstract

Inhibiting the formation and release of host asparagine cures invasive group A streptococcal infections in mice.

Funder

ASCRS Research Foundation

Planning and Budgeting Committee of the Council for Higher Education of Israel

University Grants Commission - Sri Lanka

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference61 articles.

1. Streptococcal Infections of Skin and Soft Tissues

2. A. Efstratiou T. Lamagni Epidemiology of Streptococcus pyogenes in Streptococcus pyogenes: Basic Biology to Clinical Manifestations J. J. Ferretti D. L. Stevens V. A. Fischetti Eds. (University of Oklahoma Health Sciences Center 2016).

3. The M protein of group A Streptococcus is a key virulence factor and a clinically relevant strain identification marker

4. Rise and Persistence of Global M1T1 Clone ofStreptococcus pyogenes

5. Emergence of dominant toxigenic M1T1 Streptococcus pyogenes clone during increased scarlet fever activity in England: a population-based molecular epidemiological study

Cited by 7 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Asparagine couples group AStreptococcalmetabolism to virulence;2024-07-08

2. Chemical-mediated virulence: the effects of host chemicals on microbial virulence and potential new antivirulence strategies;Canadian Journal of Microbiology;2024-06-21

3. Antibiotic resistance: a global crisis, problems and solutions;Critical Reviews in Microbiology;2024-02-21

4. Cellular battle against endoplasmic reticulum stress and its adverse effect on health;Life Sciences;2023-06

5. Periorbital necrotizing fasciitis;Survey of Ophthalmology;2022-09