Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis

Author:

Tapmeier Thomas T.12ORCID,Rahmioglu Nilufer13ORCID,Lin Jianghai14,De Leo Bianca5,Obendorf Maik5ORCID,Raveendran Muthuswamy6ORCID,Fischer Oliver M.5,Bafligil Cemsel7ORCID,Guo Manman7ORCID,Harris Ronald Alan6ORCID,Hess-Stumpp Holger5ORCID,Laux-Biehlmann Alexis5,Lowy Ernesto3ORCID,Lunter Gerton8ORCID,Malzahn Jessica7ORCID,Martin Nicholas G.9ORCID,Martinez Fernando O.10ORCID,Manek Sanjiv11,Mesch Stefanie5,Montgomery Grant W.912,Morris Andrew P.313,Nagel Jens5ORCID,Simmons Heather A.14ORCID,Brocklebank Denise3,Shang Catherine1ORCID,Treloar Susan9ORCID,Wells Graham7,Becker Christian M.1,Oppermann Udo7ORCID,Zollner Thomas M.5ORCID,Kennedy Stephen H.1ORCID,Kemnitz Joseph W.1415ORCID,Rogers Jeffrey61416ORCID,Zondervan Krina T.13ORCID

Affiliation:

1. Oxford Endometriosis CaRe Centre, Nuffield Department of Women’s & Reproductive Health, University of Oxford, Women’s Centre, John Radcliffe Hospital, Oxford OX3 9DU, UK.

2. Department of Obstetrics and Gynaecology, Monash University, Clayton, Victoria 3168, Australia.

3. Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.

4. Institute of Life and Health Engineering, College of Life Science and Technology, Jinan University, Guangzhou, Guangdong 510632, PR China.

5. Bayer AG Pharmaceuticals, Research & Development, Building S107, 13342 Berlin, Germany.

6. Human Genome Sequencing Center, Baylor College of Medicine, Houston, TX 77030, USA.

7. Nuffield Department of Orthopedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Botnar Research Centre, Oxford OX3 7LD, UK.

8. MRC Weatherall Institute of Molecular Medicine, University of Oxford, John Radcliffe Hospital, Oxford OX3 9DS, UK.

9. QIMR Berghofer Medical Research Institute, Brisbane, Queensland 4006, Australia.

10. Faculty of Health and Medical Sciences, University of Surrey, Guildford GU2 7YH, UK.

11. Department of Pathology, Oxford University Hospitals Foundation Trust, Oxford OX3 9DU, UK.

12. Institute for Molecular Bioscience, University of Queensland, Brisbane, Queensland 4072, Australia.

13. Division of Musculoskeletal and Dermatological Sciences, University of Manchester, Manchester M13 9PL, UK.

14. Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53715, USA.

15. Department of Cell & Regenerative Biology and Wisconsin National Primate Research Center, University of Wisconsin-Madison, Madison, WI 53706, USA.

16. Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA.

Abstract

Genetic analyses in humans and macaques followed by cellular and mouse studies demonstrate NPSR1 as a nonhormonal drug target in endometriosis.

Funder

Wellcome Trust Centre for Mitochondrial Research

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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