Immune responses to SARS-CoV-2 infection in hospitalized pediatric and adult patients

Author:

Pierce Carl A.1ORCID,Preston-Hurlburt Paula2,Dai Yile2,Aschner Clare Burn1ORCID,Cheshenko Natalia3ORCID,Galen Benjamin4ORCID,Garforth Scott J.5ORCID,Herrera Natalia G.5ORCID,Jangra Rohit K.1ORCID,Morano Nicholas C.5ORCID,Orner Erika6ORCID,Sy Sharlene3ORCID,Chandran Kartik1ORCID,Dziura James7ORCID,Almo Steven C.5,Ring Aaron2ORCID,Keller Marla J.4ORCID,Herold Kevan C.27ORCID,Herold Betsy C.13ORCID

Affiliation:

1. Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

2. Department of Immunobiology, Yale University, New Haven, CT 06520, USA.

3. Department of Pediatrics, The Children’s Hospital at Montefiore and Albert Einstein College of Medicine, Bronx, NY 10461, USA.

4. Department of Medicine, Montefiore Medical Center, Bronx, NY 10467, USA.

5. Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA.

6. Department of Pathology, Montefiore Medical Center, Bronx, NY 10467, USA.

7. Department of Emergency Medicine and Biostatistics, Yale University, New Haven, CT 06520, USA.

Abstract

Differences in immune responses to SARS-CoV-2 in children and adults are linked to clinical outcomes.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference29 articles.

1. Johns Hopkins Coronavirus Resource Center COVID-19 United States Cases by County (Johns Hopkins University 2020); https://coronavirus.jhu.edu/us-map [accessed 2020 August 11].

2. Hospitalization and Mortality among Black Patients and White Patients with Covid-19

3. Presenting Characteristics, Comorbidities, and Outcomes Among 5700 Patients Hospitalized With COVID-19 in the New York City Area

4. NYC Dept of Health and Mental Hygiene " NYC Coronavirus Disease 2019 (COVID-19) Data " (New York City 2020).

5. Computational Inference of Selection Underlying the Evolution of the Novel Coronavirus, Severe Acute Respiratory Syndrome Coronavirus 2

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