Neuronal delivery of antibodies has therapeutic effects in animal models of botulism-Reference-Cited by-同舟云学术

Neuronal delivery of antibodies has therapeutic effects in animal models of botulism

Published:2021-01-06 Issue:575 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

McNutt Patrick M.¹²^ORCID,Vazquez-Cintron Edwin J.²³⁴⁵^ORCID,Tenezaca Luis³⁴^ORCID,Ondeck Celinia A.²^ORCID,Kelly Kyle E.²,Mangkhalakhili Mark²^ORCID,Machamer James B.²^ORCID,Angeles Christopher A.³^ORCID,Glotfelty Elliot J.²^ORCID,Cika Jaclyn³^ORCID,Benjumea Cesar H.³^ORCID,Whitfield Justin T.⁴^ORCID,Band Philip A.³⁴⁶,Shoemaker Charles B.⁷^ORCID,Ichtchenko Konstantin³^ORCID

Affiliation:

1. Wake Forest School of Medicine, Wake Forest Institute for Regenerative Medicine, Winston-Salem, NC 27101, USA.

2. United States Army Medical Research Institute of Chemical Defense, Aberdeen Proving Ground, MD 21010, USA.

3. Department of Biochemistry and Molecular Pharmacology, New York University Grossman School of Medicine, New York, NY 10016, USA.

4. CytoDel Inc., New York, NY 10016, USA.

5. City College of City University of New York, NY 10031, USA.

6. Department of Orthopaedic Surgery, New York University Langone Orthopedic Hospital, New York, NY 10016, USA.

7. Department of Infectious Diseases and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, MA 01536, USA.

Abstract

Intraneuronal delivery of a therapeutic, single-domain antibody reverses botulism symptoms and increases survival of mice, guinea pigs, and monkeys.

Funder

National Institute of Allergy and Infectious Diseases

Defense Threat Reduction Agency

CytoDel Inc

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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