PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer

Author:

Bosch Ana1,Li Zhiqiang1,Bergamaschi Anna2,Ellis Haley1,Toska Eneda1,Prat Aleix34,Tao Jessica J.5,Spratt Daniel E.6,Viola-Villegas Nerissa T.6,Castel Pau1,Minuesa Gerard7,Morse Natasha1,Rodón Jordi89,Ibrahim Yasir10,Cortes Javier8,Perez-Garcia Jose8,Galvan Patricia3,Grueso Judit10,Guzman Marta10,Katzenellenbogen John A.11,Kharas Michael7,Lewis Jason S.67,Dickler Maura12,Serra Violeta10,Rosen Neal7,Chandarlapaty Sarat11213,Scaltriti Maurizio1,Baselga José11213

Affiliation:

1. Human Oncology and Pathogenesis Program and Memorial Sloan Kettering Cancer Center, 1275 York Avenue, Box 20, New York, NY 10065, USA.

2. Department of Molecular and Integrative Physiology, University of Illinois at Urbana-Champaign, 524 Burrill Hall, Urbana, IL 61801, USA.

3. Translational Genomics Group, Vall d’Hebron Institute of Oncology (VHIO), Passeig Vall d’Hebron 119-129, Barcelona 08035, Spain.

4. Translational Genomics and Targeted Therapeutics in Solid Tumors, August Pi i Sunyer Biomedical Research Institute, Hospital Clinic Barcelona, C/Rosselló 149-153, Barcelona 08035, Spain.

5. Massachusetts General Hospital Cancer Center and Harvard Medical School, 425 13th Street, Charlestown, MA 02129, USA.

6. Department of Radiology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

7. Molecular Pharmacology and Chemistry Program and Center for Cell Engineering, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

8. Department of Medical Oncology, VHIO, Barcelona 08035, Spain.

9. Universitat Autònoma de Barcelona, Plaza Cívica, Campus UAB, 08193 Bellaterra, Spain.

10. Experimental Therapeutics Group, VHIO, Barcelona 08035, Spain.

11. Department of Chemistry, University of Illinois at Urbana-Champaign, Urbana, IL 61801, USA.

12. Breast Medicine Service, Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

13. Weill Cornell Medical College, New York, NY 10065, USA.

Abstract

Inhibition of the PI3K/AKT pathway results in induction of ER-dependent transcriptional activity and susceptibility to anti-estrogen therapy in ER-positive breast cancer.

Funder

Breast Cancer Research Foundation

Damon Runyon Foundation

Entertainment Industry Foundation

European Research Council

Instituto de Salud Carlos III

Banco Bilbao Vizcaya Argentaria Foundation

Instituto de Salut Carlos III

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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