Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma-Reference-Cited by-同舟云学术

Calcium-sensing receptor antagonists abrogate airway hyperresponsiveness and inflammation in allergic asthma

Published:2015-04-22 Issue:284 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yarova Polina L.¹,Stewart Alecia L.²,Sathish Venkatachalem²,Britt Rodney D.²,Thompson Michael A.²,P. Lowe Alexander P.³,Freeman Michelle²,Aravamudan Bharathi²,Kita Hirohito⁴,Brennan Sarah C.¹,Schepelmann Martin¹,Davies Thomas¹,Yung Sun¹,Cholisoh Zakky³,Kidd Emma J.³,Ford William R.³,Broadley Kenneth J.³,Rietdorf Katja⁵,Chang Wenhan⁶,Bin Khayat Mohd E.⁷,Ward Donald T.⁷,Corrigan Christopher J.⁸,T. Ward Jeremy P.⁸,Kemp Paul J.¹,Pabelick Christina M.²,Prakash Y. S.²,Riccardi Daniela¹

Affiliation:

1. School of Biosciences, Cardiff University, Cardiff CF10 3AX, UK.

2. Department of Anesthesiology, Mayo Clinic, Rochester, MN 55905, USA.

3. Division of Pharmacology, Cardiff University, School of Pharmacy and Pharmaceutical Sciences, Cardiff University, Cardiff CF10 3XF, UK.

4. Department of Medicine, Mayo Clinic, Rochester, MN 55905, USA.

5. Department of Life, Health and Chemical Sciences, The Open University, Milton Keynes MK7 6AA, UK.

6. Department of Medicine, UCSF School of Medicine, San Francisco, CA 94143, USA.

7. Faculty of Life Sciences, University of Manchester, Manchester M13 9PT, UK.

8. Division of Asthma, Allergy and Lung Biology, King’s College London, London SE1 9RT, UK.

Abstract

Calcilytics reduce airway hyperresponsiveness and inflammation and may represent effective asthma therapeutics.

Funder

U. S. NIH

Biotechnology and Biological Sciences Research Council

Asthma UK

Cardiff Partnership Fund

Marie Curie Initial Training Network

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

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4. Elevated levels of peripheral-blood, naturally occurring aliphatic polyamines in bronchial asthmatic patients with active symptoms

5. Increased Ornithine-Derived Polyamines Cause Airway Hyperresponsiveness in a Mouse Model of Asthma

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