Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier-Reference-Cited by-同舟云学术

Interferon-λ restricts West Nile virus neuroinvasion by tightening the blood-brain barrier

Published:2015-04-22 Issue:284 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Lazear Helen M.¹,Daniels Brian P.²,Pinto Amelia K.¹,Huang Albert C.³,Vick Sarah C.¹,Doyle Sean E.⁴,Gale Michael³,Klein Robyn S.¹²⁵,Diamond Michael S.¹⁵⁶

Affiliation:

1. Department of Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA.

2. Department of Anatomy & Neurobiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

3. Department of Immunology, University of Washington School of Medicine, Seattle, WA 98195, USA.

4. ZymoGenetics, a Bristol-Myers Squibb Company, Seattle, WA 98102, USA.

5. Department of Pathology & Immunology, Washington University School of Medicine, St. Louis, MO 63110, USA.

6. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.

Abstract

Interferon-λ signaling tightens the blood-brain barrier and limits the ability of West Nile virus to infect the central nervous system in mice.

Funder

NSF

NIH

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference39 articles.

1. Interferon-Lambda: A New Addition to an Old Family

2. An Important Role for Type III Interferon (IFN-λ/IL-28) in TLR-Induced Antiviral Activity

3. IFN-Lambda (IFN-λ) Is Expressed in a Tissue-Dependent Fashion and Primarily Acts on Epithelial Cells In Vivo

4. Lambda Interferon Renders Epithelial Cells of the Respiratory and Gastrointestinal Tracts Resistant to Viral Infections

5. IFN- determines the intestinal epithelial antiviral host defense

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