Immunological mechanisms of the antitumor effects of supplemental oxygenation-Reference-Cited by-同舟云学术

Immunological mechanisms of the antitumor effects of supplemental oxygenation

Published:2015-03-04 Issue:277 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Hatfield Stephen M.¹,Kjaergaard Jorgen¹,Lukashev Dmitriy¹,Schreiber Taylor H.²,Belikoff Bryan¹,Abbott Robert¹,Sethumadhavan Shalini¹,Philbrook Phaethon¹,Ko Kami¹,Cannici Ryan¹,Thayer Molly¹,Rodig Scott³,Kutok Jeffrey L.³,Jackson Edwin K.⁴,Karger Barry⁵,Podack Eckhard R.²,Ohta Akio¹,Sitkovsky Michail V.¹⁶

Affiliation:

1. New England Inflammation and Tissue Protection Institute, Northeastern University, 360 Huntington Avenue, Boston, MA 02115, USA.

2. Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL 33136, USA.

3. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, 20 Shattuck Street, Boston, MA 02115, USA.

4. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15219, USA.

5. Barnett Institute of Chemical and Biological Analysis, Northeastern University, Boston, MA 02115, USA.

6. Cancer Vaccine Center, Dana-Farber Cancer Institute, Harvard Institutes of Medicine, 44 Binney Street, Boston, MA 02115, USA.

Abstract

Respiratory hyperoxia stimulates lung tumor regression by promoting T cell infiltration into the tumors and decreasing immunosuppression.

Funder

NIH

National Cancer Institute

National Institute of Allergy and Infectious Diseases

Bankhead-Coley Postdoctoral Fellowship

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference49 articles.

1. Role of G-protein-coupled adenosine receptors in downregulation of inflammation and protection from tissue damage

2. A2A adenosine receptor protects tumors from antitumor T cells

3. Purinergic Signaling during Inflammation

4. GsProtein-Coupled Adenosine Receptor Signaling and Lytic Function of Activated NK Cells

5. T regulatory cells: hypoxia-adenosinergic suppression and re-direction of the immune response

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