Glutamine-based PET imaging facilitates enhanced metabolic evaluation of gliomas in vivo

Author:

Venneti Sriram1,Dunphy Mark P.2,Zhang Hanwen3,Pitter Kenneth L.4,Zanzonico Patrick5,Campos Carl6,Carlin Sean D.7,La Rocca Gaspare4,Lyashchenko Serge8,Ploessl Karl9,Rohle Daniel46,Omuro Antonio M.10,Cross Justin R.11,Brennan Cameron W.512,Weber Wolfgang A.23,Holland Eric C.13,Mellinghoff Ingo K.610,Kung Hank F.9,Lewis Jason S.378,Thompson Craig B.46

Affiliation:

1. Department of Pathology, University of Michigan, Ann Arbor, MI 41809, USA.

2. Molecular Imaging and Therapy Service, Department of Radiology, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY 10065, USA.

3. Molecular Pharmacology and Chemistry Program, MSKCC, New York, NY 10065, USA.

4. Cancer Biology and Genetics Program, MSKCC, New York, NY 10065, USA.

5. Medical Physics, MSKCC, New York, NY 10065, USA.

6. Human Oncology and Pathogenesis Program, MSKCC, New York, NY 10065, USA.

7. Radiochemistry and Imaging Sciences Service, Department of Radiology, MSKCC, New York, NY 10065, USA.

8. Radiochemistry and Molecular Imaging Probe Core, MSKCC, New York, NY 10065, USA.

9. Departments of Radiology and Pharmacology, University of Pennsylvania, Philadelphia, PA 19104, USA.

10. Department of Neurology, MSKCC, New York, NY 10065, USA.

11. Donald B. and Catherine C. Marron Cancer Metabolism Center, MSKCC, New York, NY 10065, USA.

12. Department of Neurosurgery, MSKCC, New York, NY 10065, USA.

13. Director, Solid Tumor Translational Research, Division of Human Biology, Fred Hutchinson Cancer Research Center, and Alvord Brain Tumor Center, University of Washington, Seattle, WA 98109, USA.

Abstract

Glutamine-based PET imaging takes advantage of gliomas’ glutamine addiction and can be used to assess metabolic nutrient uptake in gliomas.

Funder

NIH

NIH Cancer Center Support Grant

National Cancer Institute (NCI)

NCI

National Institute of Neurological Disorders and Stroke (NINDS)

Stand Up to Cancer Dream Team Translational Research Grant

MSKCC Brain Tumor Center

National Institute of General Medical Sciences Medical Scientist Training Program (NIGMS MSTP)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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