A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity-Reference-Cited by-同舟云学术

A screen of approved drugs and molecular probes identifies therapeutics with anti–Ebola virus activity

Published:2015-06-03 Issue:290 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Johansen Lisa M.¹,DeWald Lisa Evans²,Shoemaker Charles J.³,Hoffstrom Benjamin G.¹,Lear-Rooney Calli M.²,Stossel Andrea²,Nelson Elizabeth³,Delos Sue E.³,Simmons James A.³,Grenier Jill M.¹,Pierce Laura T.¹,Pajouhesh Hassan¹,Lehár Joseph¹⁴,Hensley Lisa E.²,Glass Pamela J.²,White Judith M.³,Olinger Gene G.²

Affiliation:

1. Horizon Discovery Inc., 245 First Street, Cambridge, MA 02142, USA.

2. U.S. Army Medical Research Institute of Infectious Diseases, 1425 Porter Street, Frederick, MD 21702, USA.

3. University of Virginia, 1340 Jefferson Park Avenue, Charlottesville, VA 22908, USA.

4. Bioinformatics Program, Boston University, 20 Cummington Street, Boston, MA 02215, USA.

Abstract

Several FDA-approved drugs, including bepridil and sertraline, may be therapeutics against filovirus infections.

Funder

NIH

Defense Threat Reduction Agency

DTRA

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference58 articles.

1. Pathogenesis of filoviral haemorrhagic fevers

2. Postexposure protection of non-human primates against a lethal Ebola virus challenge with RNA interference: a proof-of-concept study

3. World Health Organization Ebola virus disease; http://www.who.int/mediacentre/factsheets/fs103/en/.

4. Ebola virus: new insights into disease aetiopathology and possible therapeutic interventions

5. M. Chan WHO Director-General addresses the UN Economic and Social Council on the Ebola threat. Keynote address at the Special Meeting of the Economic and Social Council on “Ebola: A threat to economic and social progress ” New York NY 5 December 2014; http://www.who.int/dg/speeches/2014/ecosoc-ebola-meeting/en/.

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