Neuronal PAC 1 receptors mediate delayed activation and sensitization of trigeminocervical neurons: Relevance to migraine-Reference-Cited by-同舟云学术

Neuronal PAC 1 receptors mediate delayed activation and sensitization of trigeminocervical neurons: Relevance to migraine

Published:2015-10-07 Issue:308 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Akerman Simon¹²,Goadsby Peter J.¹³

Affiliation:

1. Headache Group, Department of Neurology, University of California, San Francisco, San Francisco, CA 94158, USA.

2. Department of Oral and Maxillofacial Pathology, Radiology and Medicine, New York University College of Dentistry, New York, NY 10010, USA.

3. National Institute for Health Research–Wellcome Trust Clinical Research Facility, King’s College London, London SE5 9PJ, UK.

Abstract

PACAP-38 action within the brain causes delayed activation and sensitization of central trigeminovascular neurons, a likely mechanism for migraine and target for therapeutics.

Funder

Sandler Family Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference44 articles.

1. Migraine prevalence, disease burden, and the need for preventive therapy

2. Sensitization of the Trigeminovascular Pathway: Perspective and Implications to Migraine Pathophysiology

3. Neurobiology of migraine

4. Chemical Stimulation of the Intracranial Dura Induces Enhanced Responses to Facial Stimulation in Brain Stem Trigeminal Neurons

5. An association between migraine and cutaneous allodynia

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