Regulation of immune responses to protein therapeutics by transplacental induction of T cell tolerance-Reference-Cited by-同舟云学术

Regulation of immune responses to protein therapeutics by transplacental induction of T cell tolerance

Published:2015-02-18 Issue:275 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Gupta Nimesh¹²³,Culina Slobodan⁴⁵⁶,Meslier Yann¹²³,Dimitrov Jordan¹²³,Arnoult Christophe⁷,Delignat Sandrine¹²³,Gangadharan Bagirath¹²³,Lecerf Maxime¹²³,Justesen Sune⁸,Gouilleux-Gruart Valérie⁷⁹,Salomon Benoit L.³¹⁰,Scott David W.¹¹,Kaveri Srinivas V.¹²³¹²,Mallone Roberto⁴⁵⁶¹³,Lacroix-Desmazes Sébastien¹²³¹²

Affiliation:

1. INSERM, U1138, F-75006 Paris, France.

2. Centre de Recherche des Cordeliers (CRC), Equipe - Immunopathology and Therapeutic Immunointervention, F-75006 Paris, France.

3. Sorbonne Universités, Université Pierre et Marie Curie (UPMC)–Paris 6, UMR S 1138 and UMR S CR7, F-75006 Paris, France.

4. INSERM, U1016, Institut Cochin, F-75014 Paris, France.

5. CNRS, UMR8104, F-75014 Paris, France.

6. Université Paris Descartes, Sorbonne Paris Cité, F-75006 Paris, France.

7. Université François-Rabelais de Tours, CNRS, Génétique, Immunothérapie, Chimie et Cancer (GICC), UMR 7292, F-37032 Tours, France.

8. Laboratory of Experimental Immunology, Faculty of Health Sciences, University of Copenhagen, 2200 Copenhagen, Denmark.

9. CHRU de Tours, Laboratory of Immunology, F-37044 Tours, France.

10. CNRS, ERL 8255, INSERM U1135, F-75013 Paris, France.

11. Uniformed Services University of the Health Sciences, Bethesda, MD 20814, USA.

12. Laboratoire International Associé IMPACT (INSERM, France–Indian Council of Medical Research, India), F-75006 Paris, France.

13. Assistance Publique Hôpitaux de Paris, Service de Diabétologie, Hôpital Cochin, F-75014 Paris, France.

Abstract

Transplacental modulation of T cell repertoire during immune ontogeny leads to antigen-specific immune tolerance to an immunogenic protein therapeutic.

Funder

Juvenile Diabetes Research Foundation

Novo Nordisk European Programme

European Foundation for the Study of Diabetes

Agence Nationale de la Recherche

INSERM

CNRS

UPMC-Paris 6

Departement Hospitalo-Universitaire (DHU)

Fondation Recherche Medicale

Publisher

American Association for the Advancement of Science (AAAS)