Neuregulin stimulation of cardiomyocyte regeneration in mice and human myocardium reveals a therapeutic window

Author:

Polizzotti Brian D.12,Ganapathy Balakrishnan13,Walsh Stuart12,Choudhury Sangita12,Ammanamanchi Niyatie13,Bennett David G.4,dos Remedios Cristobal G.5,Haubner Bernhard J.6,Penninger Josef M.6,Kühn Bernhard12378

Affiliation:

1. Department of Cardiology, Boston Children’s Hospital, Boston, MA 02115, USA.

2. Department of Pediatrics, Harvard Medical School, Boston, MA 02115, USA.

3. Department of Pediatrics, University of Pittsburgh, and Richard King Mellon Institute for Pediatric Research and Division of Pediatric Cardiology, Children’s Hospital of Pittsburgh of UPMC, Pittsburgh, PA 15224, USA.

4. Preclinical MRI Core, Beth Israel Deaconess Medical Center, Boston, MA 02115, USA.

5. Department of Anatomy, Bosch Institute, The University of Sydney, Sydney, New South Wales 2006, Australia.

6. Institute of Molecular Biotechnology of the Austrian Academy of Sciences, 1030 Vienna, Austria.

7. Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

8. Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA 02138, USA.

Abstract

The growth factor neuregulin stimulates heart muscle repair in newborn mice and heart muscle from human infants if given during a specific therapeutic time period.

Funder

NIH

Richard King Mellon Institute for Pediatric Research

Fondation Leducq Transatlantic Network of Excellence Award

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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