Urinary metabolic signatures of human adiposity

Author:

Elliott Paul1,Posma Joram M.12,Chan Queenie1,Garcia-Perez Isabel2,Wijeyesekera Anisha2,Bictash Magda2,D. Ebbels Timothy M.2,Ueshima Hirotsugu3,Zhao Liancheng4,van Horn Linda5,Daviglus Martha56,Stamler Jeremiah5,Holmes Elaine2,Nicholson Jeremy K.2

Affiliation:

1. Department of Epidemiology and Biostatistics, Medical Research Council–Public Health England (MRC-PHE) Centre for Environment and Health, School of Public Health, Imperial College London, London W2 1PG, UK.

2. Biomolecular Medicine, Division of Computational and Systems Medicine, MRC–National Institute for Health Research (MRC-NIHR) National Phenome Centre, MRC-PHE Centre for Environment and Health, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.

3. Department of Health Science, Shiga University of Medical Science, Otsu 520-2192, Japan.

4. Department of Epidemiology, Fu Wai Hospital and Cardiovascular Institute, Chinese Academy of Medical Sciences, Beijing, Beijing 100037, People’s Republic of China.

5. Department of Preventive Medicine, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

6. College of Medicine at Chicago, University of Illinois at Chicago, Chicago, IL 60612, USA.

Abstract

In a large-scale population-based metabolic phenotyping study, diverse sets of urinary metabolites, including gut microbial co-metabolites, were reproducibly associated with human adiposity.

Funder

National Heart, Lung, and Blood Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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