Vitamin D–dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma-Reference-Cited by-同舟云学术

Vitamin D–dependent induction of cathelicidin in human macrophages results in cytotoxicity against high-grade B cell lymphoma

Published:2015-04-08 Issue:282 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Bruns Heiko¹,Büttner Maike²,Fabri Mario³,Mougiakakos Dimitrios¹,Bittenbring Jörg T.⁴,Hoffmann Markus H.⁵,Beier Fabian⁶,Pasemann Shirin¹,Jitschin Regina¹,Hofmann Andreas D.¹,Neumann Frank⁴,Daniel Christoph²,Maurberger Anna¹,Kempkes Bettina⁷,Amann Kerstin²,Mackensen Andreas¹,Gerbitz Armin¹

Affiliation:

1. Department of Internal Medicine 5–Hematology/Oncology, University Hospital Erlangen, 91054 Erlangen, Germany.

2. Department of Nephropathology, Institute of Pathology, University Hospital Erlangen, 91054 Erlangen, Germany.

3. Department of Dermatology and Center for Molecular Medicine, University of Cologne, 50937 Cologne, Germany.

4. Medizinische Klinik I, Saarland University Medical School, 66424 Homburg/Saar, Germany.

5. Department of Internal Medicine 3, University Hospital Erlangen, 91054 Erlangen, Germany.

6. Department of Oncology, Hematology and Stem Cell Transplantation, RWTH Medical School, 52074 Aachen, Germany.

7. Department of Gene Vectors, Helmholtz Center Munich, German Research Center for Environmental Health, 85764 Munich, Germany.

Abstract

Vitamin D promotes tumoricidal activity of macrophages and improves the efficacy of antibody-dependent cellular cytotoxicity.

Funder

Deutsche Forschungsgemeinschaft

Austrian Science Fund

Bavarian Immunotherapy Network

Ministry of Innovation, Science, Research and Technology

IZKF Erlangen

ELAN Fund of the University Hospital of Erlangen, Germany

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. Tumour-educated macrophages promote tumour progression and metastasis

2. CD40 Agonists Alter Tumor Stroma and Show Efficacy Against Pancreatic Carcinoma in Mice and Humans

3. Macrophages as mediators of tumor immunosurveillance

4. The Innate Mononuclear Phagocyte Network Depletes B Lymphocytes through Fc Receptor–dependent Mechanisms during Anti-CD20 Antibody Immunotherapy

5. Macrophages eliminate circulating tumor cells after monoclonal antibody therapy

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