Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli-Reference-Cited by-同舟云学术

Genetic variants associated with autoimmunity drive NFκB signaling and responses to inflammatory stimuli

Published:2015-06-10 Issue:291 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Housley William J.¹,Fernandez Salvador D.¹,Vera Kenneth¹,Murikinati Sasidhar R.¹,Grutzendler Jaime¹,Cuerdon Nicole²,Glick Laura²,De Jager Phillip L.²³,Mitrovic Mitja¹,Cotsapas Chris¹³⁴,Hafler David A.¹³

Affiliation:

1. Department of Neurology and Immunobiology, Yale School of Medicine, New Haven, CT 06511, USA.

2. Program in Translational NeuroPsychiatric Genomics, Department of Neurology, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA 02115, USA.

3. Broad Institute of Harvard University and Massachusetts Institute of Technology, Cambridge, MA 02142, USA.

4. Department of Genetics, Yale School of Medicine, New Haven, CT 06511, USA.

Abstract

Genetic variants associated with multiple sclerosis result in increased NFκB signaling in CD4 T cells and a decreased threshold for activation.

Funder

NIH

National Institute of General Medical Sciences

National Institute of Allergy and Infectious Disease

National Institute of Neurological Disorders and Stroke

National Multiple Sclerosis Society

Nancy Taylor Foundation for Chronic Disease

Penates Foundation