SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma-Reference-Cited by-同舟云学术

SLC7A11 expression is associated with seizures and predicts poor survival in patients with malignant glioma

Published:2015-05-27 Issue:289 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Robert Stephanie M.¹,Buckingham Susan C.¹,Campbell Susan L.¹,Robel Stefanie¹,Holt Kenneth T.¹,Ogunrinu-Babarinde Toyin¹,Warren Paula P.²,White David M.³,Reid Meredith A.³,Eschbacher Jenny M.⁴,Berens Michael E.⁴,Lahti Adrienne C.³,Nabors Louis B.²,Sontheimer Harald¹

Affiliation:

1. Department of Neurobiology, Center for Glial Biology in Medicine, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

2. Division of Neuro-oncology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

3. Department of Psychiatry and Behavioral Neurobiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.

4. Cancer and Cell Biology Division, Translational Genomics Research Institute (TGen), Phoenix, AZ 85004, USA.

Abstract

SLC7A11, the catalytic subunit of the cystine/glutamate antiporter, System x c − (SXC), is up-regulated in a subpopulation of patient gliomas, where it is responsible for excitotoxic glutamate release, accelerated tumor growth, and tumor-associated seizures.

Funder

NIH

Ben & Catherine Ivy Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference61 articles.

1. In vivo assessment of high-grade glioma biochemistry using microdialysis: a study of energy-related molecules, growth factors and cytokines

2. Blockage of Ca2+-permeable AMPA receptors suppresses migration and induces apoptosis in human glioblastoma cells

3. Excitotoxicity and stroke: Identifying novel targets for neuroprotection

4. Delayed post-conditioning reduces post-ischemic glutamate level and improves protein synthesis in brain

5. Glutamate release by primary brain tumors induces epileptic activity

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