Plasticity of the human visual system after retinal gene therapy in patients with Leber’s congenital amaurosis

Author:

Ashtari Manzar12,Zhang Hui3,Cook Philip A.4,Cyckowski Laura L.5,Shindler Kenneth S.12,Marshall Kathleen A.6,Aravand Puya12,Vossough Arastoo5,Gee James C.4,Maguire Albert M.126,Baker Chris I.7,Bennett Jean126

Affiliation:

1. Center for Advanced Retinal and Ocular Therapeutics, University of Pennsylvania Perelman School of Medicine, 309 Stellar-Chance Labs, 422 Curie Boulevard, Philadelphia, PA 19104, USA.

2. F.M. Kirby Center for Molecular Ophthalmology, Scheie Eye Institute, Department of Ophthalmology, University of Pennsylvania, Philadelphia, PA 19014, USA.

3. Department of Computer Science and Centre for Medical Image Computing, University College London, Gower Street, London WC1E 6BT, UK.

4. Penn Image Computing and Science Laboratory, Department of Radiology, University of Pennsylvania, 3600 Market Street, Philadelphia, PA 19104, USA.

5. Department of Radiology, The Children’s Hospital of Philadelphia, Philadelphia, PA 19014, USA.

6. Center for Cellular and Molecular Therapeutics at The Children’s Hospital of Philadelphia, Colket Translational Research Building, 3501 Civic Center Boulevard, Philadelphia, PA 19014, USA.

7. Laboratory of Brain and Cognition, National Institutes of Health, 10 Center Drive, MSC 1240, Bethesda, MD 20892, USA.

Abstract

Imaging reveals increased structural and functional plasticity in human visual pathways after retinal gene therapy.

Funder

NIH

National Institute of Mental Health

F.M. Kirby Foundation

Research to Prevent Blindness

University of Pennsylvania

Foundation Fighting Blindness

Transdisciplinary Awards Program in Translational Medicine and Therapeutics (TAPITMAT)

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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