Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults

Author:

Ogwang Caroline1,Kimani Domtila1,Edwards Nick J.23,Roberts Rachel23,Mwacharo Jedidah1,Bowyer Georgina3,Bliss Carly3,Hodgson Susanne H.23,Njuguna Patricia1,Viebig Nicola K.4,Nicosia Alfredo567,Gitau Evelyn1,Douglas Sandy23,Illingworth Joe3,Marsh Kevin12,Lawrie Alison2,Imoukhuede Egeruan B.24,Ewer Katie3,Urban Britta C.8,S. Hill Adrian V.23,Bejon Philip12,Leroy Odile,Cisse Badara,Sirima Sodiomon,Bojang Kalifa,Murphy Georgina,Karanja Henry,Nyamako Lydiah,De Cassan Simone,Awuondo Ken,Kwiatkowski Dominic,Rockett Kirk,Gilbert Sarah,Anagnostou Nicholas,Soipei Peninah,Peshu Judy,Petersen Ines,Mutinda Brian,Waithira Naomi,Bashraheil Mahfudh,Shangala Jimmy,Moyle Sarah,Berrie Eleanor,Targett Geoffrey,Thera Mahamadou,Milligan Paul,Ogutu Bernhards,Etyang Anthony,

Affiliation:

1. Centre for Geographic Medicine Research, Kenya Medical Research Institute–Wellcome Trust Research Programme, PO Box 230, 80108 Kilifi, Kenya.

2. Centre for Clinical Vaccinology and Tropical Medicine, Oxford OX3 7BN, UK.

3. The Jenner Institute, Oxford OX3 7BN, UK.

4. European Vaccine Initiative, 69120 Heidelberg, Germany.

5. ReiThera, Viale Città d’Europa 679, 00144 Rome, Italy.

6. CEINGE, Via Gaetano Salvatore 486, 80145 Naples, Italy.

7. Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

8. Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Abstract

Vaccination with the recombinant viral vectors chimpanzee adenovirus 63 followed by modified vaccinia Ankara both encoding the malaria sequence ME-TRAP conferred 67% protection against infection with Plasmodium falciparum in Kenyan adults.

Funder

Wellcome Trust

Wellcome Trust Centre for Human Genetics

Senior Wellcome Trust Fellowship

U.K. Medical Research Council (MRC)

U.K. Department for International Development (DFID)

European and Developing Countries Clinical Trials Partnership

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

同舟云学术

1.学者识别学者识别

2.学术分析学术分析

3.人才评估人才评估

"同舟云学术"是以全球学者为主线,采集、加工和组织学术论文而形成的新型学术文献查询和分析系统,可以对全球学者进行文献检索和人才价值评估。用户可以通过关注某些学科领域的顶尖人物而持续追踪该领域的学科进展和研究前沿。经过近期的数据扩容,当前同舟云学术共收录了国内外主流学术期刊6万余种,收集的期刊论文及会议论文总量共计约1.5亿篇,并以每天添加12000余篇中外论文的速度递增。我们也可以为用户提供个性化、定制化的学者数据。欢迎来电咨询!咨询电话:010-8811{复制后删除}0370

www.globalauthorid.com

TOP

Copyright © 2019-2024 北京同舟云网络信息技术有限公司
京公网安备11010802033243号  京ICP备18003416号-3