Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults-Reference-Cited by-同舟云学术

Prime-boost vaccination with chimpanzee adenovirus and modified vaccinia Ankara encoding TRAP provides partial protection against Plasmodium falciparum infection in Kenyan adults

Published:2015-05-06 Issue:286 Volume:7 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ogwang Caroline¹,Kimani Domtila¹,Edwards Nick J.²³,Roberts Rachel²³,Mwacharo Jedidah¹,Bowyer Georgina³,Bliss Carly³,Hodgson Susanne H.²³,Njuguna Patricia¹,Viebig Nicola K.⁴,Nicosia Alfredo⁵⁶⁷,Gitau Evelyn¹,Douglas Sandy²³,Illingworth Joe³,Marsh Kevin¹²,Lawrie Alison²,Imoukhuede Egeruan B.²⁴,Ewer Katie³,Urban Britta C.⁸,S. Hill Adrian V.²³,Bejon Philip¹²,Leroy Odile,Cisse Badara,Sirima Sodiomon,Bojang Kalifa,Murphy Georgina,Karanja Henry,Nyamako Lydiah,De Cassan Simone,Awuondo Ken,Kwiatkowski Dominic,Rockett Kirk,Gilbert Sarah,Anagnostou Nicholas,Soipei Peninah,Peshu Judy,Petersen Ines,Mutinda Brian,Waithira Naomi,Bashraheil Mahfudh,Shangala Jimmy,Moyle Sarah,Berrie Eleanor,Targett Geoffrey,Thera Mahamadou,Milligan Paul,Ogutu Bernhards,Etyang Anthony,

Affiliation:

1. Centre for Geographic Medicine Research, Kenya Medical Research Institute–Wellcome Trust Research Programme, PO Box 230, 80108 Kilifi, Kenya.

2. Centre for Clinical Vaccinology and Tropical Medicine, Oxford OX3 7BN, UK.

3. The Jenner Institute, Oxford OX3 7BN, UK.

4. European Vaccine Initiative, 69120 Heidelberg, Germany.

5. ReiThera, Viale Città d’Europa 679, 00144 Rome, Italy.

6. CEINGE, Via Gaetano Salvatore 486, 80145 Naples, Italy.

7. Department of Molecular Medicine and Medical Biotechnology, University of Naples Federico II, Via S. Pansini 5, 80131 Naples, Italy.

8. Liverpool School of Tropical Medicine, Liverpool L3 5QA, UK.

Abstract

Vaccination with the recombinant viral vectors chimpanzee adenovirus 63 followed by modified vaccinia Ankara both encoding the malaria sequence ME-TRAP conferred 67% protection against infection with Plasmodium falciparum in Kenyan adults.

Funder

Wellcome Trust

Wellcome Trust Centre for Human Genetics

Senior Wellcome Trust Fellowship

U.K. Medical Research Council (MRC)

U.K. Department for International Development (DFID)

European and Developing Countries Clinical Trials Partnership

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference30 articles.