Targeting p53-dependent stem cell loss for intestinal chemoprotection-Reference-Cited by-同舟云学术

Targeting p53-dependent stem cell loss for intestinal chemoprotection

Published:2018-02-07 Issue:427 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Leibowitz Brian J.¹²^ORCID,Yang Liheng²³^ORCID,Wei Liang¹²^ORCID,Buchanan Monica E.²³^ORCID,Rachid Madani²,Parise Robert A.²^ORCID,Beumer Jan H.²³⁴⁵^ORCID,Eiseman Julie L.²³⁵,Schoen Robert E.²⁴^ORCID,Zhang Lin²³,Yu Jian¹²^ORCID

Affiliation:

1. Department of Pathology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

2. UPMC Hillman Cancer Center, Pittsburgh, PA 15213, USA.

3. Department of Pharmacology and Chemical Biology, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

4. Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA 15261, USA.

5. Department of Pharmaceutical Sciences, University of Pittsburgh School of Pharmacy, Pittsburgh, PA 15261, USA.

Abstract

Targeting of p53- and PUMA-dependent apoptosis protects intestinal stem cells, but not cancer cells, against chemotherapy.

Funder

NIAID

NCI

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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