BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions

Author:

Fard Maryam K.1ORCID,van der Meer Franziska2ORCID,Sánchez Paula1,Cantuti-Castelvetri Ludovico1,Mandad Sunit34,Jäkel Sarah5,Fornasiero Eugenio F.3ORCID,Schmitt Sebastian1,Ehrlich Marc67,Starost Laura67ORCID,Kuhlmann Tanja7,Sergiou Christina2ORCID,Schultz Verena2ORCID,Wrzos Claudia2ORCID,Brück Wolfgang2,Urlaub Henning48,Dimou Leda5910ORCID,Stadelmann Christine2ORCID,Simons Mikael1101112ORCID

Affiliation:

1. Max Planck Institute for Experimental Medicine, 37075 Göttingen, Germany.

2. Department of Neuropathology, University of Göttingen Medical Center, 37075 Göttingen, Germany.

3. Department of Neuro- and Sensory Physiology, University of Göttingen Medical Center, 37073 Göttingen, Germany.

4. Max Planck Institute for Biophysical Chemistry, 37073 Göttingen, Germany.

5. Department of Physiological Genomics, BioMedical Center, Ludwig-Maximilians-Universität München, Munich, Germany.

6. Institute of Neuropathology, University Hospital Münster, 48149 Münster, Germany.

7. Department of Cell and Developmental Biology, Max Planck Institute for Molecular Biomedicine, 48149 Münster, Germany.

8. Bioanalytical Mass Spectrometry Group, Department of Clinical Chemistry, University of Göttingen Medical Center, Robert Koch Straße 40, 37075 Göttingen, Germany.

9. Molecular and Translational Neuroscience, Department of Neurology, Medical Faculty, Ulm University, 89081 Ulm, Germany.

10. Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.

11. Institute of Neuronal Cell Biology, Technical University of Munich, 80805 Munich, Germany.

12. German Center for Neurodegenerative Diseases (DZNE), 6250 Munich, Germany.

Abstract

BCAS1 expression identifies newly formed and actively myelinating oligodendrocytes in development, adulthood, and disease.

Funder

ERC CoG

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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