Finding useful biomarkers for Parkinson’s disease

Author:

Chen-Plotkin Alice S.1ORCID,Albin Roger23,Alcalay Roy4,Babcock Debra5,Bajaj Vikram6,Bowman Dubois7,Buko Alex8,Cedarbaum Jesse9ORCID,Chelsky Daniel10ORCID,Cookson Mark R.11ORCID,Dawson Ted M.12ORCID,Dewey Richard13ORCID,Foroud Tatiana14ORCID,Frasier Mark15ORCID,German Dwight16,Gwinn Katrina5ORCID,Huang Xuemei17,Kopil Catherine15ORCID,Kremer Thomas18,Lasch Shirley19,Marek Ken19ORCID,Marto Jarrod A.202122,Merchant Kalpana23ORCID,Mollenhauer Brit2425,Naito Anna15,Potashkin Judith26ORCID,Reimer Alyssa15ORCID,Rosenthal Liana S.27ORCID,Saunders-Pullman Rachel28ORCID,Scherzer Clemens R.29ORCID,Sherer Todd15,Singleton Andrew30,Sutherland Margaret5ORCID,Thiele Ines31ORCID,van der Brug Marcel32,Van Keuren-Jensen Kendall33,Vaillancourt David34ORCID,Walt David22,West Andrew35,Zhang Jing36

Affiliation:

1. Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA 19104, USA.

2. Neurology Service and GRECC, VAAHS, Ann Arbor, MI 48105, USA.

3. Department of Neurology, University of Michigan, Ann Arbor, MI 48109, USA.

4. Department of Neurology, Columbia University Medical Center, New York, NY 10032, USA.

5. National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD 20824, USA.

6. Verily/Google Life Sciences, South San Francisco, CA 94080, USA.

7. Department of Biostatistics, Mailman School of Public Health, Columbia University, New York, NY 10032, USA.

8. Human Metabolome Technology–America, Boston, MA 02134, USA.

9. Biogen, Cambridge, MA 02142, USA.

10. Caprion Biosciences, Montreal, Quebec H2X 3Y7, Canada.

11. Cell Biology and Gene Expression Section, Laboratory of Neurogenetics, National Institute of Aging, National Institutes of Health, Bethesda, MD 20892, USA.

12. Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.

13. Department of Neurology and Neurotherapeutics, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

14. Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN 46202, USA.

15. The Michael J. Fox Foundation for Parkinson’s Research, New York, NY 10163, USA.

16. Department of Psychiatry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.

17. Department of Neurology, Penn State University–Hershey Medical Center, Hershey, PA 17033, USA.

18. Pharmaceutical Research and Early Development, NORD Discovery and Translational Area, Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd., 4070 Basel, Switzerland.

19. Institute for Neurodegenerative Disorders, New Haven, CT 06510, USA.

20. Departments of Cancer Biology and Pathology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

21. Blais Proteomics Center, Dana-Farber Cancer Institute, Harvard Medical School, Boston, MA 02215, USA.

22. Department of Pathology, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02215, USA.

23. Chaperone Therapeutics, Portland, OR 97229, USA.

24. Paracelsus-Elena-Klinik, 34128 Kassel, Germany.

25. University Medical Center, 37075 Goettingen, Germany.

26. Department of Cellular and Molecular Pharmacology, Chicago Medical School, Rosalind Franklin University of Medicine and Science, Chicago, IL 60064, USA.

27. Department of Neurology, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA.

28. Department of Neurology, Mount Sinai Beth Israel, Icahn School of Medicine at Mount Sinai, New York, NY 10003, USA.

29. Center for Advanced Parkinson’s Disease Research and Precision Neurology Program, Brigham and Women’s Hospital, Harvard Medical School, Boston, MA 02115, USA.

30. Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.

31. Luxembourg Centre for Systems Biomedicine, University of Luxembourg, Luxembourg, Luxembourg.

32. Genentech, San Francisco, CA 94080, USA.

33. Neurogenomics Division, Translational Genomics Research Institute, Phoenix, AZ 85004, USA.

34. Department of Applied Physiology, Biomedical Engineering, and Neurology, University of Florida, Gainesville, FL 32611, USA.

35. Department of Neurology, University of Alabama, Birmingham, AL 35233, USA.

36. Department of Pathology, University of Washington, Seattle, WA 98195, USA.

Abstract

The recent advent of an “ecosystem” of shared biosample biorepositories and data sets will aid efforts to define biomarkers for Parkinson’s disease.

Funder

Michael J. Fox Foundation for Parkinson’s Research

National Institutes of Neurological Disorders and Stroke

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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