Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats-Reference-Cited by-同舟云学术

Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats

Published:2018-07-04 Issue:448 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Rajani Rikesh M.¹^ORCID,Quick Sophie¹^ORCID,Ruigrok Silvie R.¹^ORCID,Graham Delyth²^ORCID,Harris Sarah E.³^ORCID,Verhaaren Benjamin F. J.⁴⁵^ORCID,Fornage Myriam⁵⁶,Seshadri Sudha⁵⁷^ORCID,Atanur Santosh S.⁸,Dominiczak Anna F.²^ORCID,Smith Colin⁹,Wardlaw Joanna M.¹⁰^ORCID,Williams Anna¹^ORCID

Affiliation:

1. Medical Research Council (MRC) Centre for Regenerative Medicine and UK Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4UU, UK.

2. Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8QQ, UK.

3. Centre for Cognitive Ageing and Cognitive Epidemiology and MRC Institute of Genetics and Molecular Medicine, University of Edinburgh, Edinburgh EH4 2LF, UK.

4. Erasmus Medical Centre, 3015 CE Rotterdam, Netherlands.

5. Neurology Working Group of the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE).

6. Institute of Molecular Medicine, University of Texas Health Science Center, Houston, TX 77030, USA.

7. Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.

8. Centre for Genomic and Experimental Medicine, University of Edinburgh, Edinburgh EH4 2LF, UK.

9. Academic Neuropathology, Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh EH16 4SB, UK.

10. Brain Research Imaging Centre, Centre for Clinical Brain Sciences, and UK Dementia Research Institute, University of Edinburgh, Edinburgh EH16 4SB, UK.

Abstract

Endothelial cell–stabilizing drugs reverse white matter pathology in a rat model of cerebral small vessel disease.

Funder

Medical Research Council

Fondation Leducq

BBSRC

Alzheimer’s Research UK

BHF Centre of Research Excellence, Glasgow

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine