Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8-Reference-Cited by-同舟云学术

Plasmacytoid dendritic cells promote systemic sclerosis with a key role for TLR8

Published:2018-01-10 Issue:423 Volume:10 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Ah Kioon Marie Dominique¹^ORCID,Tripodo Claudio²^ORCID,Fernandez David³^ORCID,Kirou Kyriakos A.³^ORCID,Spiera Robert F.⁴,Crow Mary K.¹³^ORCID,Gordon Jessica K.⁴,Barrat Franck J.¹^ORCID

Affiliation:

1. Autoimmunity and Inflammation Program, HSS Research Institute, Hospital for Special Surgery, New York, NY 10021, USA.

2. Tumor Immunology Unit, Department of Health Science, Human Pathology Section, University of Palermo School of Medicine, Palermo, Italy.

3. Mary Kirkland Center for Lupus Research, Hospital for Special Surgery, New York, NY 10021, USA.

4. Scleroderma and Vasculitis Center, Hospital for Special Surgery, New York, NY 10021, USA.

Abstract

The production of CXCL4 and IFN-α by plasmacytoid DCs in response to TLR8 signaling contributes to skin fibrosis and systemic sclerosis.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference55 articles.

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2. Systemic Sclerosis

3. Prevalence, incidence, survival, and disease characteristics of systemic sclerosis in a large US population

4. B-Lymphocyte Depletion Reduces Skin Fibrosis and Autoimmunity in the Tight-Skin Mouse Model for Systemic Sclerosis

5. B cell depletion with rituximab in patients with diffuse cutaneous systemic sclerosis

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