Advancing beyond the twists and turns of T cell exhaustion in cancer-Reference-Cited by-同舟云学术

Advancing beyond the twists and turns of T cell exhaustion in cancer

Published:2022-11-09 Issue:670 Volume:14 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

van der Heide Verena¹^ORCID,Humblin Etienne¹^ORCID,Vaidya Abishek¹^ORCID,Kamphorst Alice Oliffson¹²³^ORCID

Affiliation:

1. Marc and Jennifer Lipschultz Precision Immunology Institute, Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.

2. Department of Oncological Sciences, ISMMS, New York, NY 10029, USA.

3. Tisch Cancer Institute, ISMMS, New York, NY 10029, USA.

Abstract

Chronic antigen stimulation leads to T cell exhaustion. Nutrient restrictions and other suppressive factors in the tumor microenvironment further exacerbate T cell dysfunction. Better understanding of heterogeneity and dynamics of exhausted CD8 T cells will guide novel therapies that modulate T cell differentiation to achieve more effective antitumor responses.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference34 articles.

1. Not-so-opposite ends of the spectrum: CD8+ T cell dysfunction across chronic infection, cancer and autoimmunity

2. T cell differentiation in chronic infection and cancer: functional adaptation or exhaustion?

3. Tumor-Specific T Cell Dysfunction Is a Dynamic Antigen-Driven Differentiation Program Initiated Early during Tumorigenesis

4. Epigenetic scarring of exhausted T cells hinders memory differentiation upon eliminating chronic antigenic stimulation

5. Shared and distinct biological circuits in effector, memory and exhausted CD8+ T cells revealed by temporal single-cell transcriptomics and epigenetics

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