Genetic and epigenetic inactivation of SESTRIN1 controls mTORC1 and response to EZH2 inhibition in follicular lymphoma

Author:

Oricchio Elisa1ORCID,Katanayeva Natalya1ORCID,Donaldson Maria Christine1ORCID,Sungalee Stephanie1ORCID,Pasion Joyce P.2ORCID,Béguelin Wendy3,Battistello Elena14ORCID,Sanghvi Viraj R.2,Jiang Man2ORCID,Jiang Yanwen5,Teater Matt5ORCID,Parmigiani Anita6ORCID,Budanov Andrei V.67,Chan Fong Chun89,Shah Sohrab P.1011ORCID,Kridel Robert812ORCID,Melnick Ari M.3,Ciriello Giovanni4,Wendel Hans-Guido2ORCID

Affiliation:

1. Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

2. Cancer Biology and Genetics Program, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.

3. Division of Hematology/Oncology, Weill Cornell Medical College, Cornell University, 1300 York Avenue, New York, NY 10065, USA.

4. Department of Computational Biology, University of Lausanne, 1005 Lausanne, Switzerland.

5. Institute for Computational Biomedicine, Weill Cornell Medical College, Cornell University, New York, NY 10065, USA.

6. Department of Human and Molecular Genetics, Goodwin Research Laboratories, Massey Cancer Center, Virginia Commonwealth University, Richmond, VA 23298, USA.

7. School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Pearse Street, Dublin 2, Ireland.

8. Centre for Lymphoid Cancer, BC Cancer Agency, Vancouver, British Columbia V5Z 1L3, Canada.

9. Bioinformatics Graduate Program, University of British Columbia, Vancouver, British Columbia, Canada.

10. Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.

11. Department of Molecular Oncology, BC Cancer Agency, Vancouver, British Columbia, Canada.

12. Division of Medical Oncology and Hematology, Princess Margaret Cancer Centre, Toronto, Ontario, Canada.

Abstract

SESTRIN1 is a tumor suppressor deleted or epigenetically silenced by mutated EZH2.

Funder

American Cancer Society

NIH Office of the Director

Swiss National Science Foundation

National Cancer Institute

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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