TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis-Reference-Cited by-同舟云学术

TGFβ2 and TGFβ3 isoforms drive fibrotic disease pathogenesis

Published:2021-08-04 Issue:605 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Sun Tianhe¹^ORCID,Huang Zhiyu²,Liang Wei-Ching³,Yin Jianping⁴^ORCID,Lin Wei Yu³^ORCID,Wu Jia³^ORCID,Vernes Jean-Michel⁵,Lutman Jeff⁶,Caplazi Patrick⁷^ORCID,Jeet Surinder²^ORCID,Wong Tiffany⁴^ORCID,Wong Manda⁴^ORCID,DePianto Daryle J.¹^ORCID,Morshead Katrina B.¹^ORCID,Sun Kai-Hui⁸^ORCID,Modrusan Zora⁸,Vander Heiden Jason A.⁹^ORCID,Abbas Alexander R.⁹^ORCID,Zhang Hua²,Xu Min²^ORCID,N’Diaye Elsa-Noah¹,Roose-Girma Meron¹⁰^ORCID,Wolters Paul J.¹¹^ORCID,Yadav Rajbharan⁶^ORCID,Sukumaran Siddharth⁶,Ghilardi Nico¹^ORCID,Corpuz Racquel⁴^ORCID,Emson Claire²^ORCID,Meng Y. Gloria⁵^ORCID,Ramalingam Thirumalai R.¹²,Lupardus Patrick⁴^ORCID,Brightbill Hans D.²^ORCID,Seshasayee Dhaya³^ORCID,Wu Yan³,Arron Joseph R.¹^ORCID

Affiliation:

1. Department of Immunology Discovery, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

2. Department of Translational Immunology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

3. Department of Antibody Engineering, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

4. Department of Structural Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

5. Department of Biochemical and Cellular Pharmacology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

6. Department of Preclinical and Translational Pharmacokinetics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

7. Department of Pathology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

8. Department of Protein Sciences, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

9. Department of OMNI Bioinformatics, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

10. Department of Molecular Biology, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

11. Department of Medicine, University of California, San Francisco, San Francisco, CA 94143, USA.

12. Department of Biomarker Discovery OMNI, Genentech Inc., 1 DNA Way, South San Francisco, CA 94080, USA.

Abstract

TGFβ2 and TGFβ3 isoforms are activated via unique mechanisms and are associated with fibrosis in human diseases.

Funder

Genentech

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference89 articles.

1. The Impact of TGF-β on Lung Fibrosis

2. TGF-β in progression of liver disease

3. Transforming growth factor β—at the centre of systemic sclerosis

4. Cross Talk among TGF- Signaling Pathways, Integrins, and the Extracellular Matrix

5. Specificity, versatility, and control of TGF-β family signaling

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