Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers-Reference-Cited by-同舟云学术

Replication stress response defects are associated with response to immune checkpoint blockade in nonhypermutated cancers

Published:2021-10-27 Issue:617 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

McGrail Daniel J.¹^ORCID,Pilié Patrick G.²,Dai Hui¹^ORCID,Lam Truong Nguyen Anh²^ORCID,Liang Yulong¹,Voorwerk Leonie³,Kok Marleen³⁴,Zhang Xiang H.-F.⁵⁶⁷⁸^ORCID,Rosen Jeffrey M.⁵⁶^ORCID,Heimberger Amy B.⁹¹⁰^ORCID,Peterson Christine B.¹¹^ORCID,Jonasch Eric²^ORCID,Lin Shiaw-Yih¹^ORCID

Affiliation:

1. Department of Systems Biology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

2. Department of Genitourinary Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

3. Division of Tumor Biology and Immunology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

4. Department of Medical Oncology, The Netherlands Cancer Institute, 1066 CX Amsterdam, Netherlands.

5. Department of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX 77030, USA.

6. Dan L. Duncan Cancer Center, Baylor College of Medicine, Houston, TX 77030, USA.

7. Lester and Sue Smith Breast Center, Baylor College of Medicine, Houston, TX 77030, USA.

8. McNair Medical Institute, Baylor College of Medicine, Houston, TX 77030, USA.

9. Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

10. Malnati Brain Tumor Institute of the Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.

11. Department of Biostatistics, The University of Texas MD Anderson Cancer Center, Houston, TX 77030, USA.

Abstract

Endogenous and induced replication stress response defects promote tumor immunogenicity via generation of cytosolic single-stranded DNA.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference70 articles.

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