GDE2-RECK controls ADAM10 α-secretase–mediated cleavage of amyloid precursor protein-Reference-Cited by-同舟云学术

GDE2-RECK controls ADAM10 α-secretase–mediated cleavage of amyloid precursor protein

Published:2021-03-17 Issue:585 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Nakamura Mai¹^ORCID,Li Yuhan¹,Choi Bo-Ran¹^ORCID,Matas-Rico Elisa²^ORCID,Troncoso Juan³,Takahashi Chiaki⁴^ORCID,Sockanathan Shanthini¹^ORCID

Affiliation:

1. The Solomon H. Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, 725 N Wolfe Street, PCTB 1004, Baltimore, MD 21205, USA.

2. Division of Cell Biology, The Netherlands Cancer Institute, Plesmanlaan, CX 1066 Amsterdam, Netherlands.

3. Department of Neurology, Department of Pathology, Johns Hopkins University School of Medicine, 600 N Wolfe Street, Baltimore, MD 21205, USA.

4. Cancer Research Institute, Kanazawa University, Kakuma-Cho, Kanazawa City 920-1192, Japan.

Abstract

GDE2 controls surface amounts of the metalloprotease inhibitor RECK to promote ADAM10 α-secretase activity and prevent Aβ production and synapse loss.

Funder

National Institutes of Health

American Federation for Aging Research

This

American Foundation for Aging Research

Alzheimer’s Disease Research Center, Emory University

Johns Hopkins University

Johns Hopkins Alzheimer’s Disease Research Center Pilot Project Award

Johns Hopkins Innovation Award

Johns Hopkins President’s Frontier Finalist Award

Publisher

American Association for the Advancement of Science (AAAS)