Wolframin-1–expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice-Reference-Cited by-同舟云学术

Wolframin-1–expressing neurons in the entorhinal cortex propagate tau to CA1 neurons and impair hippocampal memory in mice

Published:2021-09-15 Issue:611 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Delpech Jean-Christophe¹²^ORCID,Pathak Dhruba³,Varghese Merina⁴^ORCID,Kalavai Srinidhi Venkatesan¹^ORCID,Hays Emma C.³^ORCID,Hof Patrick R.⁴^ORCID,Johnson W. Evan⁵^ORCID,Ikezu Seiko¹,Medalla Maria³⁶^ORCID,Luebke Jennifer I.³⁶^ORCID,Ikezu Tsuneya¹⁶⁷^ORCID

Affiliation:

1. Department of Pharmacology and Experimental Therapeutics, Boston University School of Medicine, Boston, MA, USA.

2. University of Bordeaux, INRAE, Bordeaux INP, NutriNeuro, UMR 1286, F-33000 Bordeaux, France.

3. Anatomy and Neurobiology, Boston University School of Medicine, Boston, MA, USA.

4. Nash Family Department of Neuroscience, Friedman Brain Institute, and Ronald C. Loeb Center for Alzheimer’s Disease, Icahn School of Medicine at Mount Sinai, New York, NY, USA.

5. Computational Biomedicine, Boston University School of Medicine, Boston, MA, USA.

6. Center for Systems Neuroscience, Boston University, Boston, MA, USA.

7. Department of Neuroscience, Mayo Clinic, Jacksonville, FL, USA.

Abstract

Wolframin-1–positive neurons in the entorhinal cortex of mouse brain propagate tau to the hippocampal CA1 region resulting in memory impairment.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

Reference50 articles.

1. Neuropathological stageing of Alzheimer-related changes

2. Alzheimer's Disease: Cell-Specific Pathology Isolates the Hippocampal Formation