Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro-Reference-Cited by-同舟云学术

Plasma from patients with bacterial sepsis or severe COVID-19 induces suppressive myeloid cell production from hematopoietic progenitors in vitro

Published:2021-06-16 Issue:598 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Reyes Miguel¹²^ORCID,Filbin Michael R.¹³^ORCID,Bhattacharyya Roby P.¹⁴^ORCID,Sonny Abraham⁵^ORCID,Mehta Arnav¹⁶^ORCID,Billman Kianna¹^ORCID,Kays Kyle R.³,Pinilla-Vera Mayra⁷,Benson Maura E.⁷^ORCID,Cosimi Lisa A.⁷^ORCID,Hung Deborah T.¹⁷^ORCID,Levy Bruce D.⁷^ORCID,Villani Alexandra-Chloe¹⁸^ORCID,Sade-Feldman Moshe¹⁶^ORCID,Baron Rebecca M.⁷^ORCID,Goldberg Marcia B.¹⁴^ORCID,Blainey Paul C.¹²⁹^ORCID,Hacohen Nir¹⁶^ORCID

Affiliation:

1. Broad Institute of MIT and Harvard, Cambridge, MA, USA.

2. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA, USA.

3. Department of Emergency Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

4. Center for Bacterial Pathogenesis, Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

5. Department of Anesthesia, Critical Care, and Pain Medicine, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

6. Center for Cancer Research, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

7. Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women’s Hospital and Harvard Medical School, Boston, MA, USA.

8. Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.

9. Koch Institute for Integrative Cancer Research at MIT, Cambridge, MA, USA.

Abstract

Cytokines in plasma from sepsis or severe COVID-19 patients induce production of suppressive myeloid cells from hematopoietic progenitors in vitro.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

American Lung Association

Massachusetts General Hospital

University of Maryland School of Public Health

Publisher

American Association for the Advancement of Science (AAAS)