Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis-Reference-Cited by-同舟云学术

Hepatocyte TLR4 triggers inter-hepatocyte Jagged1/Notch signaling to determine NASH-induced fibrosis

Published:2021-06-23 Issue:599 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Yu Junjie¹^ORCID,Zhu Changyu¹^ORCID,Wang Xiaobo¹^ORCID,Kim KyeongJin¹^ORCID,Bartolome Alberto¹^ORCID,Dongiovanni Paola²^ORCID,Yates Katherine P.³,Valenti Luca⁴⁵^ORCID,Carrer Michele⁶^ORCID,Sadowski Thorsten⁷^ORCID,Qiang Li⁸,Tabas Ira¹⁸⁹^ORCID,Lavine Joel E.¹⁰,Pajvani Utpal B.¹^ORCID

Affiliation:

1. Department of Medicine, Columbia University, New York, NY 10032, USA.

2. General Medicine and Metabolic Diseases, Fondazione IRCCS Ca’ Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.

3. Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA.

4. Department of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan 20122, Italy.

5. Translational Medicine, Department of Transfusion Medicine and Hematology, Fondazione IRCCS Cà Granda Ospedale Maggiore Policlinico, Milan 20122, Italy.

6. Ionis Pharmaceuticals Inc., Carlsbad, CA 92010, USA.

7. Sanofi-Aventis, Frankfurt 65926, Germany.

8. Department of Pathology and Cell Biology, Columbia University, New York, NY 10032, USA.

9. Department of Physiology, Columbia University, New York, NY 10032, USA.

10. Department of Pediatrics, Columbia University, New York, NY 10032, USA.

Abstract

Increased Jagged1 in pericentral hepatocytes causes liver fibrosis in response to hepatocyte TLR4–NF-κB pathway activation in NASH.

Funder

National Institute of Diabetes and Digestive and Kidney Diseases

American Liver Foundation

Stiftelsen för Kunskaps- och Kompetensutveckling

Russell Berrie Foundation