SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations-Reference-Cited by-同舟云学术

SHP2 drives inflammation-triggered insulin resistance by reshaping tissue macrophage populations

Published:2021-04-28 Issue:591 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Paccoud Romain¹^ORCID,Saint-Laurent Céline¹²^ORCID,Piccolo Enzo¹²^ORCID,Tajan Mylène¹²,Dortignac Alizée¹,Pereira Ophélie¹²^ORCID,Le Gonidec Sophie¹²,Baba Inès³^ORCID,Gélineau Adélaïde³,Askia Haoussa³^ORCID,Branchereau Maxime¹^ORCID,Charpentier Julie¹,Personnaz Jean¹^ORCID,Branka Sophie¹^ORCID,Auriau Johanna¹^ORCID,Deleruyelle Simon¹^ORCID,Canouil Mickaël⁴^ORCID,Beton Nicolas⁵^ORCID,Salles Jean-Pierre⁵^ORCID,Tauber Maithé⁵^ORCID,Weill Jacques⁴,Froguel Philippe⁴⁶,Neel Benjamin G.⁷^ORCID,Araki Toshiyuki⁷^ORCID,Heymes Christophe¹,Burcelin Rémy¹,Castan Isabelle¹²^ORCID,Valet Philippe¹²^ORCID,Dray Cédric¹²^ORCID,Gautier Emmanuel L.³^ORCID,Edouard Thomas²⁵^ORCID,Pradère Jean-Philippe¹²,Yart Armelle¹²^ORCID

Affiliation:

1. Institut des Maladies Métaboliques et Cardiovasculaires, INSERM UMR 1048, Université Paul Sabatier, Université de Toulouse, Toulouse F-31432, France.

2. RESTORE, INSERM UMR1301, CNRS UMR5070, Université Paul Sabatier, Université de Toulouse, Toulouse F-31100, France.

3. INSERM UMR-S 1166, Sorbonne Université, Hôpital de la Pitié-Salpêtrière, Paris F-75013, France.

4. INSERM UMR 1283, CNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille University Hospital, Lille F-59000, France.

5. Endocrine, Bone Diseases, and Genetics Unit, Children’s Hospital, Toulouse University Hospital, Toulouse France and Centre de Physiopathologie Toulouse-Purpan, INSERM UMR 1043, Université Paul Sabatier, Université de Toulouse, Toulouse F-31024, France.

6. Department of Metabolism, Digestion and Reproduction, Imperial College London, London SW7 2AZ, UK.

7. Laura and Isaac Perlmutter Cancer Center, NYU-Langone Medical Center, NY 10016, USA.

Abstract

Hyperactive SHP2 promotes inflammation-driven insulin resistance by skewing macrophage balance in metabolic tissues and may be a target in T2D.

Funder

Horizon 2020 Framework Programme

H2020 Health

Emissions Reduction Alberta

Agence Nationale de la Recherche

Fondation pour la Recherche Médicale

University Hospital Toulouse

Agence Nationale