Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases-Reference-Cited by-同舟云学术

Microglial activation states drive glucose uptake and FDG-PET alterations in neurodegenerative diseases

Published:2021-10-13 Issue:615 Volume:13 Page:
ISSN:1946-6234
Container-title:Science Translational Medicine
language:en
Short-container-title:Sci. Transl. Med.

Author:

Xiang Xianyuan¹²^ORCID,Wind Karin³⁴,Wiedemann Thomas³,Blume Tanja³⁴,Shi Yuan⁴,Briel Nils⁴⁵^ORCID,Beyer Leonie³^ORCID,Biechele Gloria³,Eckenweber Florian³,Zatcepin Artem³⁴^ORCID,Lammich Sven¹,Ribicic Sara⁴^ORCID,Tahirovic Sabina⁴^ORCID,Willem Michael¹^ORCID,Deussing Maximilian³,Palleis Carla⁴⁶^ORCID,Rauchmann Boris-Stephan⁷⁸^ORCID,Gildehaus Franz-Josef³,Lindner Simon³,Spitz Charlotte⁹,Franzmeier Nicolai¹⁰^ORCID,Baumann Karlheinz¹¹,Rominger Axel³¹²^ORCID,Bartenstein Peter³¹³,Ziegler Sibylle³¹³,Drzezga Alexander¹⁴¹⁵¹⁶,Respondek Gesine¹⁷,Buerger Katharina⁴¹⁰,Perneczky Robert⁴⁸¹³¹⁸^ORCID,Levin Johannes⁴⁶¹³^ORCID,Höglinger Günter U.⁴¹³¹⁷¹⁹^ORCID,Herms Jochen⁴⁵¹³,Haass Christian¹⁴¹³^ORCID,Brendel Matthias³⁴¹³^ORCID

Affiliation:

1. Biomedical Center (BMC), Division of Metabolic Biochemistry, Faculty of Medicine, Ludwig-Maximilians-Universität München, 81377 Munich, Germany.

2. CAS Key Laboratory of Brain Connectome and Manipulation, Brain Cognition and Brain Disease Institute, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences; Shenzhen-Hong Kong Institute of Brain Science-Shenzhen Fundamental Research Institutions, 518055 Shenzhen, China.

3. Department of Nuclear Medicine, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.

4. German Center for Neurodegenerative Diseases (DZNE) Munich, 81377 Munich, Germany.

5. Center for Neuropathology and Prion Research, Ludwig-Maximilians-University München, 81377 Munich, Germany.

6. Department of Neurology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.

7. Department of Radiology, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.

8. Department of Psychiatry and Psychotherapy, University Hospital of Munich, LMU Munich, 81377 Munich, Germany.

9. Institute of Biochemistry and Molecular Biology, University of Augsburg, 86159 Augsburg, Germany.

10. Institute for Stroke and Dementia Research (ISD), University Hospital of Munich, LMU Munich, 81377 Munich, Germany.

11. Roche, Pharma Research and Early Development, NORD DTA/Neuroscience Discovery, Roche Innovation Center Basel, F. Hoffmann–La Roche Ltd., Grenzacherstrasse 124, CH-4070 Basel, Switzerland.

12. Department of Nuclear Medicine, University of Bern, Inselspital, CH-3010 Bern, Switzerland.

13. Munich Cluster for Systems Neurology (SyNergy), 81377 Munich, Germany.

14. Department of Nuclear Medicine, Faculty of Medicine, University Hospital Cologne, University of Cologne, 5091 Cologne, Germany.

15. German Center for Neurodegenerative Diseases (DZNE) Bonn-Cologne, 53127 Bonn, Germany.

16. Institute of Neuroscience and Medicine (INM-2), Molecular Organization of the Brain, Forschungszentrum Jülich, 52425 Jülich, Germany.

17. Department of Neurology, Hannover Medical School, 30625 Hannover, Germany.

18. Ageing Epidemiology (AGE) Research Unit, School of Public Health, Imperial College, London SW7 2AZ, UK.

19. Department of Neurology, Technical University Munich, 81675 Munich, Germany.

Abstract

FDG-PET shows that microglial activation might drive cerebral glucose uptake in mice and patients with AD.

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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