Load-induced regulation of tendon homeostasis by SPARC, a genetic predisposition factor for tendon and ligament injuries

Author:

Wang Tao12ORCID,Wagner Andrea34ORCID,Gehwolf Renate34ORCID,Yan Wenjin5ORCID,Passini Fabian S.67ORCID,Thien Christine1,Weissenbacher Nadja34ORCID,Lin Zhen12,Lehner Christine34ORCID,Teng Huajian8ORCID,Wittner Claudia9ORCID,Zheng Qiujian2ORCID,Dai Jin5ORCID,Ni Ming110ORCID,Wang Allan1ORCID,Papadimitriou John111,Leys Toby1,Tuan Rocky S.1213ORCID,Senck Sasha9ORCID,Snedeker Jess G.67ORCID,Tempfer Herbert34ORCID,Jiang Qing5ORCID,Zheng Ming H.114ORCID,Traweger Andreas34ORCID

Affiliation:

1. Centre for Orthopaedic Translational Research, Medical School, University of Western Australia, Nedlands, Western Australia 6009,Australia.

2. Division of Orthopaedic Surgery, Department of Surgery, Guangdong Provincial People’sHospital, Guangdong Academy of Medical Sciences, Guangzhou, Guangdong 510000, China.

3. Institute of Tendon and Bone Regeneration, Paracelsus Medical University–Spinal Cord Injury and Tissue Regeneration Center Salzburg, 5020 Salzburg, Austria.

4. Austrian Cluster for Tissue Regeneration, 1200 Vienna, Austria.

5. State Key Laboratory of Pharmaceutical Biotechnology, Department of Sports Medicine and Adult Reconstructive Surgery, Nanjing Drum Tower Hospital, Affiliated Hospital of Nanjing University Medical School, Nanjing 210008, China.

6. University Hospital Balgrist, University of Zurich, Zürich, Switzerland.

7. Institute for Biomechanics, ETH Zurich, 8008 Zürich, Switzerland.

8. Laboratory for Bone and Joint Disease, Model Animal Research Center (MARC), Nanjing University, Nanjing 210008, China.

9. Computed Tomography Research Group, University of Applied Sciences Upper Austria, 4600 Wels, Austria.

10. Department of Orthopaedics, General Hospital of Chinese People’s Liberation Army, Beijing 100853, China.

11. PathWest Laboratories, Nedlands, Western Australia 6009, Australia.

12. Center for Cellular and Molecular Engineering, Department of Orthopaedic Surgery, University of Pittsburgh School of Medicine, Pittsburgh, PA 15213, USA.

13. Institute for Tissue Engineering and Regenerative Medicine, Chinese University of Hong Kong, Hong Kong SAR, China.

14. Perron Institute for Neurological and Translational Science, Nedlands, Western Australia 6009, Australia.

Abstract

The extracellular matrix protein SPARC modulates load sensing in tendons and is critical for tissue maturation and homeostasis.

Funder

National Health and Medical Research Council

National Natural Science Foundation of China

Guangdong Science and Technology Department

Australian Research Council Industrial Transformation Training Centre for Personalised Therapeutics Technologies

Australia Research Council Linkage Grant

Fund for the Advancement of Scientific Research at the Paracelsus Medical University

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine

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